METILMETIONINSULFONIYA CHLORIDE (S-metilmetionin, U, d,1-3-амино-З-карбокси-пропилдиметилсульфония vitamin chloride) — physiologically active agent possessing antiulcerous action. For the first time M. x. it was received by synthesis from methionine in 1940. Antiulcerous action of M. x. it was open in 1950 — 1960 in the course of studying of antiulcerous effect of cabbage juice. It turned out that a major factor in to lay down. effect of cabbage juice at a peptic ulcer of a stomach and duodenum is contained in this juice M. x. It represents methyl derivative amino acids methionine (see), containing the additional methyl group attached to sulfur atom. Thanks to existence of positive charge on sulfur atom M. x. forms salts — chloride, bromide, etc.
M. x. — white crystal powder of sweetish and saltish taste, with a smell of cabbage; let's well dissolve in water, water alcohol, it is insoluble in absolute alcohol and ether. M.'s crystals x. are hygroscopic. During the heating and long (about one year) storage decays, it is not steady on light. In a large number contains in a white cabbage (35 — 85 mg on 100 g), an asparagus (100 — 160 mg on 100 g), greens of parsley, turnip, pepper, carrots, tomatoes, onions. It can be determined quantitatively mikrobiol, method with Lactobacillus arabinosus or colorimetric by reaction with 1,2 naphthoquinonesulphonate of potassium.
In a human body and animal M. x. actively joins in a metabolism as the donor of methyl groups in reactions biol, methylations. The most important reaction of this type is participation of methyl group M. x. in biosynthesis of methionine from a gomotsistein. It is characteristic that in this reaction two molecules of methionine are formed at once: one of a gomotsistein, another — from M. x. As donor of methyl groups M. x. is more effective, than a betaine. Nevertheless need (indispensability) of M. x. for the person and animals it is not proved therefore it cannot be carried to vitamins or other irreplaceable feedstuffs, and is vitaminopodobny connection.
M x. apply in complex therapy of patients with a peptic ulcer of a stomach - and a duodenum, hron, gastritis at normal, lowered and hypersecretion in doses but 100 mg of 3 — 5 times a day within 30 — 40 days. M.'s reception x. contributes to normalization of kislotovydelitelny function, disappearance of pains and the dispeptic phenomena, healing of an ulcer.
Mechanism of therapeutic action of M. x. completely it is not found out. It is possible that, participating in reactions of methylation, M. x. promotes an intensification of a metabolism in a mucous membrane of a stomach and intestines, stimulates the reparative processes leading to healing and scarring of an ulcer. Methylating a histamine, M. x. turns it into an inactive form that promotes reduction of gastric secretion and pains. M x. low-toxic connection. Minimum toxic dose of M. x. for white mice makes 2000 mg/kg; LD 50 2760 ± 45,3 mg/kg. At nek-ry patients at M.'s reception x. the phenomena of individual intolerance of this drug are observed: nausea, vomiting, strengthening of pains, allergic reactions etc. In such cases it is recommended to reduce a dose and if by-effects do not disappear, to stop administration of drug.
Form of release: tablets on 0,05 g in banks of orange glass. Keep in the place protected from light at t ° not higher than 20 °.
Bibliography Bukin V. N. and Huchua G. N. S-metilmetionin as an antiulcerous factor (vitamin U), in book: Lips biol, chemical, under the editorship of B. N. Stepanenko, etc., t. 10, page 184, M., 1969; Vitamin U (S-metilmetionin), under the editorship of V. N. Bukin and V. E. Anisimov, M., 1973; Vitamins, under the editorship of M. I. Smirnov, page 487, M., 1974.
V. B. Spirichev.