METHYL-ISOPROPYL PHENOL (Thymolum; GFH, joint venture. B) — helminthicide. 2-Izo-propil-5-metilfenol; With 10 H 14 О:
Large colourless crystals or crystal powder with a characteristic smell and spicy and burning taste, letuch with water vapor. We will dissolve in water very little, it is easily alcohol-soluble, chloroform, ether, fatty oils and ice acetic to - those, we will dissolve in solutions of caustic soda: pier. weight (weight) 150,22; t°pl 49 — 51 °.
T. contains in thyme oil (Oleum Thymi) received from a grass of a timian of ordinary (Thymus vulgaris) this. mint family (Labiateae). For the medical purposes T. receive from vegetable raw materials or a synthetic way. T. has activity concerning nek-ry nematodes and antiseptic properties.
As helminthicide of T. apply at to an ankilostomidoza (see), trichuriasis (see) and enterobiosis (see). At the same time for 1 — 2 day before treatment and within 1 — 2 days after it appoint a diet, excepting fats, alcohol, vinegar. The day before and in 1-2 hours after reception of T. give salt laxative. At treatment of a trichuriasis salt laxative is appointed to the 6th day in the evening. At an ankilostomidoza of T. appoint the adult in a daily dose 3 g, to-ruyu divide into 4 parts, give them with breaks of 15 — 20 min. in the form of powder with sugar or icing sugar. Treatment of an ankilostompdoz is carried out within 3 days. If necessary the course of treatment is repeated in 2 — 3 weeks. To children of T. appoint according to the same scheme in the following daily doses: from 2 to 5 years 0,2 — 0,5 g, from 6 to 8 years 0,6 — 0,8 g, from 9 to 10 years 1 — 1,2 g, from 11 to 15 years 1,2 — 2 g. To children up to 2 years drug is not appointed. Treatment of a trichuriasis is carried out by courses lasting 6 days. To adult T. appoint 0,75 — 1 g in a daily dose, to-ruyu give in one step (in the morning on an empty stomach). To children drug is appointed at the rate of 0,05 g to a year of life on reception but the same scheme. In total conduct 5 courses of treatment with six-day breaks between them.
As an antiseptic agent of T, inside but 0,1 g 2 — 3 times a day sometimes appoint at ponosa and a meteorism, and also apply in the form of 0,05 — 0,1% r ~ ra to rinsings of an oral cavity, pharynx, nasopharynx.
In dental practice of T. use as an antiseptic agent and for anesthesia of dentine. For this purpose usually apply so-called liquid of Gartman, edges 95% of alcohol 1 of h and ether 1 of h
Besides, contain methyl-isopropyl phenol 1,25 of h, T. use as preservative of nek-ry pharmaceuticals.
The highest doses for adults inside: one-time 1 g, daily 4 g.
At to overdose T. pains in epigastric area, tachycardia, dizziness, nausea, vomiting, a diarrhea, the hyperphrenia which is replaced by weakness and drowsiness are noted.
T. it is contraindicated at pregnancy, heart failure, diseases of a liver and kidneys, peptic ulcer of a stomach and duodenum.
Form of release: powder. Store in well corked container protecting from light.
See also Helminthicides .
Bibliography: A. I moles. Bases of experimental therapy of helminthoses, page 104, M., 1973; Muravyeva D. A. Pharmacognosy, page 258, M., 1978.
A. I. Krotov.