METHANDROSTENOLONE (Methandrostenolonum; synonym: Nerobolum, Anabolin, Anaboral, Dianabol, Metanabol, Novabol etc.) — artificially synthesized analog of testosterone, an anabolic steroid; stimulates synthesis of protein in skeletal muscles, a myocardium, kidneys, a liver, nervous tissue and disintegration of proteins in an organism detains, reduces allocation by kidneys of urea.
The m influences on mineral metabolism (see), slowing down release of potassium, phosphorus and sulfur, promotes accumulation of calcium in bones. At identical anabolic activity androgenic properties M. are nearly 100 times weaker, than at testosterone (cm).
The m represents white or yellowish powder, low solubility in water and it is easy — in alcohol.
Indications to M.'s use the adynamy, a cachexia of various origin, a state after injuries, burns, blood losses, and also hron serve, infections etc. M. is used for decrease in concentration of residual nitrogen, at osteoporosis and the slowed-down formation of a bone callosity after changes. In pediatric practice of M. appoint at a growth inhibition, anorexia, decline of food, etc.
At elderly people of M. sometimes apply to improvement of compensatory and adaptation processes.
M apply inside before food. Initial doses for adult 10 — 20 mg a day; in some cases the daily dose can be increased to 30 — 50 mg. At prolonged treatment of M. its dose decreases to 5 — 10 mg. A course of treatment of 4 — 8 weeks then the break for 1 — 2 month becomes.
To children drug M. is appointed depending on age. To children up to 2 years at the rate of 0,05 — 0,1 mg on 1 kg of body weight a day; children from 2 to 5 years of 1 — 2 mg daily (drug is accepted every other day), to children are from 5 to 14 years old — 3 — 5 mg a day. The daily dose of drug is given in 1 — 2 reception. A course of treatment at children no more than 4 weeks with a break between courses 6 — 8 weeks.
At M.'s use dispeptic frustration, increase in a liver, passing jaundice, hypostases are possible. At women (especially after prolonged treatment of M.) the phenomena of virilescence passing after drug withdrawal are possible.
M. it is contraindicated at a prostate cancer, acute and hron, prostatitis and at a breast cancer at men. Relative contraindications — pregnancy and the period of a lactation, cholecystitis, disturbances of a menstrual cycle.
Form of release — tablets on 1 mg and on 5 mg. Storage — the list B. In the place protected from light.
See also Anabolic steroids .
Bibliography: Mashkovsky M. D. Pharmaceuticals, p. 2, page 3, M., 1977; Pivnitsky K. K. Anabolic steroid hormones, Problems of testing and communication of activities with a structure, Probl.Endokrin., t. 20, No. 4, page 111, 1974, bibliogr.; Uzbekova D. G. Anabolic steroid means, Pharm, and toksikol., t. 37, No. 4, page 484, 1974, bibliogr.
V. I. Maximov.