METAMIZYL (Metamizylum; synonym: methyldiazil; joint venture. A) — tranquilizer. beta Diethylaminopropyl ether benzylic to - you are a hydrochloride; With 21 H 27 O 3 N • HCl:
White fine-crystalline powder. Let's dissolve in water; it will be sterilized by boiling; solutions at storage on light are hydrolyzed.
It is similar to amizyl (see) treats the central holinoblokator operating preferential on the central m - cholinereactive systems. However along with it has effect on peripheral holinoretseptor. Has the tranquilizing, spasmolytic, moderately expressed antihistaminic and antiserotoninovy properties, has mestnoanesteziruyushchy effect.
By analogy with amizyl M. apply as tranquilizing, holinoblokiruyushchy and an antispasmodic, and also to potentiation of action of analgetics and hypnagogues. In neuropathology and M.'s psychiatry apply at neurotic and depressions, phobias, contagious excitation, cerebral palsies, hyperkinesias, vascular diseases of a brain and in the acute period of a craniocereberal injury.
As a holinoblokator of M. apply at a peptic ulcer of a stomach and duodenum, a pylorospasm, bronchial asthma, intestinal and renal gripes. In anesthesiology — by preparation for operations and in the postoperative period, in ophthalmology — in the form of eye drops (1% freshly cooked solution) for a short mydriasis, along with it observes anesthesia of a cornea and conjunctiva.
M. appoint inside, intramusculary and subcutaneously. At neurotic conditions of M. appoint inside 0,0002 g of 1 — 3 time a day; at a peptic ulcer of a stomach and duodenum — inside on 0,002 — 0,005 g or subcutaneously on 1 ml of 0,25% of solution 2 — 3 times a day; in psychiatry — inside on 0,001 — 0,002 g or parenterally on 0,5 — 1 ml of 0,25% of solution 2 — 3 times a day, gradually increasing a dose before receiving sedation.
The highest doses for adults inside: one-time 0,01 g, daily 0,02 g; under skin: one-time 0,005 g (2 ml of 0,25% of solution), daily 0,015 g (6 ml of 0,25% of solution).
Side effect The m is shown by dryness in a mouth, expansion of pupils, tachycardia; euphoria and dizziness is sometimes noted. At intake of M. can cause numbness of language and the sky (in connection with mestnoanesteziruyushchy action). At overdose of drug also the hyperphrenia, hallucinations, spasms are possible motive.
M. it is contraindicated at glaucoma.
Forms of release: powder, tablets on 0,001 g, ampoules on 1 ml of 0,25% of solution. Keep in the cool, protected from light place.
Bibliography: Denisenko P. P. Central cholinolytics, L., 1965; it, the Role of holinoreaktivny systems in regulatory processes, M., 1980.