MERCAPTOPURINUM (6 Mercaptopurinum, 6-Mercaptopurinum; synonym Ismipur, Leupurin, Mercapurin, Mercaptine, Purinethol; joint venture. A) — antineoplastic means, C 5 H 4 N 4 S-H 2 O:
Inodorous yellow crystal powder, we will badly dissolve in water, we will well dissolve in solutions of alkalis and ammonia.
The m is among antimetabolites, is an antagonist of adenine, hypoxanthine; breaks biosynthesis nucleinic to - t.
The m is quickly soaked up from went. - kish. a path, it is allocated with urine not changed or in the form of 6-thiouric to - you.
The main indications to M.'s use — an acute leukosis, blast crisis hron, a myeloleukemia, a horionepiteliom of a uterus. As a rule, M. is appointed in a combination with corticosteroids (see) and antineoplastic drugs of other mechanism of action — methotrexate (see), Cyclophosphanum (see), Vincristinum , (see), rubomitsiny (see), it renders to lay down. action in cases of resistance to drugs — antagonists folic to - you.
M. apply inside in tablets on 2 — 2,5 mg on 1 kg of weight daily during the first 3 — 4 weeks; then, if there does not come the wedge, effect and there are no by-effects, the dose can be gradually raised to 5 mg/kg a day. By-effects at M.'s treatment: leukopenia, thrombocytopenia. and also loss of appetite, nausea, vomiting, diarrhea.
Form of release: tablets on 0,05 g.
Store in well corked container.
See also Antineoplastic means .
Bibliography Kovalyova L. G. Principles modern cytostatic therapies of an acute leukosis, Owls. medical, No. 8, page 111, 1973; P e r e in about d h and to about in and H. I. Clinical chemotherapy of tumoral diseases, with, 58, M., 1976.
V. A. Chernov.