From Big Medical Encyclopedia

LYMPHOMA (lymphoma; lat. lympha pure water, moisture + - oma) — a collective concept for designation of all aleukemic tumors of the hemopoietic and adenoid tissue. The term «malignant lymphoma» is for the first time offered by T. Billroth; nek-ry authors call these tumors of a gematosarkomama. Tumoral tissue of the vast majority of L. consists of lymphoid elements and their derivatives. Besides, in group L. carry also other tumors of the hemopoietic fabric as the finding signs of belonging to this or that cellular line (histiocytic, granulotsitarny), and undifferentiated.

Most often L. arise in limf, nodes, a spleen, an adenoid tissue of a ring of Valdeyer, group limf, follicles, but can appear in any other bodies and fabrics which do not have a direct bearing to hemopoietic and limf, system. Was considered that L. arise and grow autokhtonno therefore they were carried to general diseases. According to many researchers, L. — the monoclonal malignant tumors extending in the metastatic way.

It was offered apprx. 100 classifications of malignant L., constructed gl.obr. on the basis of their studying morfol, features. All of them surely included a lymphosarcoma, a reticulosarcoma, a lymphogranulomatosis and gigantofollikulyarny L.; entered nek-ry classifications hron, a lymphoid leukosis, on a number of indicators close to lymphocytic L., very seldom Hashimoto's struma, lymphoepithelioma and Ewing's sarcoma. As the working option which is subject to further specifications and additions, WHO in 1976 is offered the international histologic and cytologic classification made the Mat, Rappaport, O'Konor, Torloni (G. Mathe, H. Rappaport, G. T. O’Conor, H. Torloni). According to this classification, malignant L. are not included in general diseases and are designated by tumors of the hemopoietic and adenoid tissue, such as lymphosarcoma (see), mycosis fungoid (see), a plasmacytoma (see. Multiple myeloma), a reticulosarcoma (see), a lymphogranulomatosis (see), an eosinophilic granuloma (see), a mastocytoma (see the Reticulosarcoma). Classifications of L., to-rykh are the basis immunol, signs, degree of a zlokachestvennost and the place of formation of tumoral elements, did not gain distribution. Wedge, classifications of L., except the scheme of distribution to stages, does not exist.

Bibliography: Krayevsky H. And., It is mute yo N about in a H. M and x about x l about in and M. P. Pathological anatomy and questions of a pathogeny of leukoses, page 66, etc., m, 1965; M and with with about N of the Item. Tumors of the person,’ lane of e fr., page 80, M., 1965; In e 1 an i with h S. Classification des affections tumorales du systeme reticulo-endothelial, Med. et Hug. (Geneve), t. 24, p. 943, 1966; Current concepts in the management of lymphoma and leukemia, ed. by J. E. Ultmann a. o., L. a. o. 197G of D o r f m a n R. F. Pathology of the non-Hodgkin’s lymphomas, Cancer Treatment Rep., y. 61, p. 945, 1977, bibliogr.; J a ff e E. S. a. o. Functional markere, new perspective on malignant lymphomas, ibid., p. 953, bibliogr., L u k e s R. J. a. Co 1-1 i n s R. D. Lukes — Collins classification and its significance, ibid., v. 61, p. 971, 1977; S e 1 i g m a n n M., B r o u e t J. - C. 'a. P r e u d' of h o m m e J. - L., Immunologic classification of non-Hodgkin’ s lymphomas, ibid., p. 1179, bibliogr.: W i n i w a r t e r A. t)ber das maligne Lymphom und Lymphosarkom, mi t besonderer Riicksicht auf ihre Behandlung, Arch. klin. Chir., Bd 18, S. 98, 1875.

G. V. Kruglova.