From Big Medical Encyclopedia

URIKEMYYa [lat. (acidum) of iiricum uric acid + Greek ha ima blood] — the content of uric acid in blood.

Normal concentration uric to - you in blood serum makes at women 2 — 6 l/.> '100 ml, men

have 2,5 — 7,0 mg / 100 ml, in erythrocytes it reaches 0,8 — 3 mg / \00 ml. In blood serum uric to - that is preferential in a look mononatriye-howl urates.

And yes e r at r and to e and yu and and 11 about at r and to e m and go reveal m on a deviation of the koitsent-radio set uric to - you from the specified upper or lower bounds of norm characteristic of men and women. Such approach to definition of a hyperuricemia allows to establish degree of approximation of concentration of urates to a limit of their solubility in blood serum and to estimate degree of danger of fabric precipitation of urates. Besides, take into account the individual gineruri-kemiya established on the basis of exceeding of concentration uric to - you, inherent to this person since the individual norm is defined not only sexual, but also age, genetic and other factors. Definition of an individual hyperuricemia allows to state initial disturbances of purine exchange.

At a hyperuricemia concentration uric to - you in blood serum can reach 22 mg / ibO of ml and more. Can be the reasons of a hyperuricemia the increased synthesis uric to - you (e.g., at gout), increase in a catabolism nucleinic to - t (at miyelo-and limfoproliferativny processes, at radiation therapy, malignant new growths, etc.), decrease in renal excretion uric to - you (in some cases at primary gout, at a glomerulonephritis, an amyloidosis of kidneys, a drunkenness, etc.), excess intake of purines with food.

Considerable prevalence of a hyperuricemia at various diseases and at almost healthy faces reduces its diagnostic value in detection of any certain pathology, including gout (see), at a cut it is found in the vast majority of patients. Lech. it is necessary to apply actions at a hyperuricemia differentially — elimination etiol. a factor, use of the drugs normalizing the level of a lithemia (Allopyrinolum, etc.), purpose of a diet with the limited content of purines (see Gout).

The hypolithemia can occur also at healthy people, however in most cases its emergence is secondary and is caused or the raised uricosuria (e.g., at pregnancy, hepatocerebral dystrophy, Fankoni's syndrome, use of uricosuric drugs), or use of urikodepressivny or uricolytic means (an urikozim, etc.). The role of a gigyuurikemiya in development of any pathology is not established.

For determination of level U. two groups of methods, one of use generally to-rykh it is based on recovery of a phosphatotungstic reactant of Folin uric to - that (with the subsequent kolorimet-rirovaniye of the painted solution), another — on specific decomposition reaction uric to - you uricase (with the subsequent a kolorimet-rirovaniye or UF-spektrofotomet-riyey at wavelength to 293 them). Methods of the first group are most widespread (in connection with availability of the used reactants), however they are insufficiently strictly specific and give a little overestimated data about At. at the expense of chromogens of not urate origin (phenolic products, purine connections, etc.).

See also Uric acid.

E. G. Pikhlak.