LEVOMEPROMAZINUM (Levomepromazinum; synonym: levopromazinum, Nozinanum, Tisercinum, Levomepromazini Hydrochloridum, Levomepromazine Hydrochloride, Levopromazin, Minozinan, Nozinan, Tisercin etc.) — a neuroleptic of a fenotiazinovy row. 2-Metoksi-10-(-3-dimethylamino-2-methylpropyl) - a fenotiazina a hydrochloride; With 19 H 2 4 N 2 OS-HCl:
On pharmakol, to properties it is close to to aminazine (see). Influence of L. on mentality it is shown in block, difficulty of movements and the speech. Unlike aminazine, L. does not strengthen a depression and has antidepressive effect; surpasses aminazine in soothing, antihistaminic and hypothermal effect, and also in ability to exponentiate effect of anesthetics and analgetics, but concedes on antiemetic and holinoblokiruyushchy effects.
LEVOMEPROMAZINUM is applied by hl. obr. in psychiatry for stopping of psychomotor excitement of various etiology, and also at the agitated depressions with alarm, depressive and paranoid states and depressions with a Cotard delusion. The L is most effective. at circular schizophrenia (as at depressive, and maniacal attacks). L. it is highly effective also at alcoholic psychoses. Sometimes drug is used at the persistent sleeplessness and diseases which are followed by a pain syndrome (e.g., at neuritis, shingles, etc.).
LEVOMEPROMAZINUM is appointed inside and parenterally. At acute psychoses treatment begin 1 — 3 ml of 2,5% of solution (0,025 — 0,075 g) with parenteral administration. If necessary the daily dose is increased to 0,1 — 0,3 g (intramusculary) or to 0,1 g (in a vein). In L. appoint 0,05 — 0,1 g 3 — 4 times a day. Course treatment carry out 0,025 — 0,05 g since a daily dose and daily increasing it by 0,025 — 0,05 g to a daily dose of 0,1 — 0,3 g (in) or 0,075 — 0,2 g (parenterally). At the end of a course of treatment the dose is gradually reduced to supporting (0,025 — 0,1 g a day). For stopping of acute alcoholic psychoses of L. enter into a vein in a dose 0,05 — 0,075 g from 10 — 20 ml of 40% of solution of glucose. In need of the next 5 — 7 days enter intramusculary 0,1 — 0,15 g of drug.
LEVOMEPROMAZINUM causes the same by-effects, as well as aminazine, napr, an antipsychotic syndrome (see. Psychopharmacology ), allergic reactions, hypotonia, the dispeptic phenomena, but they are less expressed. It is contraindicated at persistent hypotonia, cardiovascular insufficiency, damages of a liver and a hemopoiesis.
Form of release: tablets (dragee) on 0,025 g and ampoules on 1 ml of 2,5% of solution. Keep in the place protected from light.
See also Antipsychotic means .
Bibliography Avrutsky G. Ya., Gurovich I. Ya. and Gromova of V. V. Pharmakoterapiya of mental diseases, M., 1974, bibliogr.
E. B. Arushanyan.