LARIONOV Leonid Fedorovich (1902 — 1973), the Soviet oncologist — himioterapevt, the academician of AMH (1969), the foreign member Korolevskogo about-va medicine in London (1958), the member correspondent. The American association on studying of cancer (1960), the winner of the State award USSR (1951).
In 1925 ended medical f-t Tomsk un-that then worked as the assistant at department patol, physiology of it un-that. In 1927 — 1930 the graduate student, since 1931 the senior research associate, and since 1937 the manager. experimental cancer department Central radiological, radiological and cancer in-that (Leningrad). In 1938 protected dokt, the thesis on a subject: «Cancer and endocrine system». Since 1940 the department chair patol, physiology Minsk medical in-that. From 1945 to 1951 the manager. laboratory of experimental therapy of cancer in Ying-those oncology of the USSR Academy of Medical Sciences; since 1951 headed laboratory of experimental chemotherapy of tumors in Ying-those experimental and a wedge, oncology of the USSR Academy of Medical Sciences.
L. F. Larionov published St. 200 scientific works, including 5 monographs which cover a wide range of questions of experimental oncology. He offered the adaptation and trophic theory of developing of tumors, according to a cut the malignancy results from adaptation of cells to the long disturbance of their food and an innervation taking place at precancerous processes (1959).
In 1948 L. F. Larionov made a hypothesis of creation of antineoplastic drugs by accession of the alkylating group to the vital metabolites or biologically active compounds which shall provide specificity of action. He called such drugs «the alkylating metabolites». As a result of researches, joint with chemists, it created a number of antineoplastic drugs. Embichinum, Novembichinum, Dopanum, sarcolysine, asalin entered practice of health care. At the same time it conducted work on clinical chemotherapy and was an initiator of creation of chemotherapeutic departments in onkol, in-ta and clinics of the USSR. For works on chemotherapy of cancer and implementation in practice of health care of chemotherapeutic drugs L. F. Larionov was conferred the State award USSR. Under its management the St. 50 theses, including 8 doctor's are prepared.
L. F. Larionov was the chairman of the Problem commission on medicinal therapy of tumors of Scientific council on malignant new growths at presidium of the USSR Academy of Medical Sciences, the consultant of UNESCO for the «Cytobiology and Radiobiology» program, the expert in chemotherapy of the International anticarcinogenic union, the associate editor of a number of the international and domestic magazines.
It is awarded the order the Labour Red Banner and medals.
Works: Cancer and endocrine system, L., 1938; Biological and chemical ways of cancer therapy, in book: Malignant tumors, under the editorship of H. N. Petrova, t. 1, p. 2, page 117, L., 1948 (sovm, with Mankin 3. Century); Treatment of a leukemia and lymphogranulomatosis Embichinum, M., 1951; Adaptatsionnotrofichesky theory of development of malignant tumors, Stalemate. fiziol, and Eksperim, rubbed., t. 3, No. 2, page 87, 1959; Precancer as pathological process, Arkh. patol., t. 21, No. 3, page 3, 1959; A new class of antitumour compounds, alkylating metabolites, in book; Cancer Progr., 1960, ed. by R. W. Raven, p. 211, L. a. o., 1960; Progress in chemotherapy of solid tumors, ibid., p. 219; Chemotherapy of malignant tumors, M., 1962; Methods of screening anticancer drugs in the Soviet Union, Cancer Chemother. Rep., v. 54, No. 2, pt 1, p. 71, 1970.
Bibliography: Leonid Fedorovich Larionov (to the 70 anniversary since birth), Vopr, onkol., t. 18, No. 10, page 117, 1972; Leonid Fedorovich Larionov, in the same place, t. 19, No. 5, page 124, 1973.
3. P. Sofyina.