From Big Medical Encyclopedia

LANDIS TEST (E. M. Landis, amer. physiologist, sort. in 1901) — a method of assessment of permeability of capillaries in size of filtering of liquid and protein from capillary blood in the conditions of the increased hydrostatic pressure. In 1932 Landis with sotr. showed what at increase venous and consequently, and capillary pressure there is an increase in capillary filtering, and amount of the filtered liquid is in direct proportionality from a difference between hydrostatic and colloid osmotic pressure.

The technique

On one hand inspected, being in horizontal position, is reached stagnation of capillary blood by imposing on a shoulder of a cuff, in a cut pressure of 40 mm of mercury is created., it is also supported within 30 min. Blood sampling from elbow veins «congestive» is made and «not stagnation ache» hands for definition of a difference in indicators of a hematocrit and the maintenance of total quantity of protein and its separate fractions.

Calculation of a fluid loss on 100 cm 3 blood of a «congestive» hand (capillary filtrate) make on a formula:

F = 100 — 100 (Hu/Hq),

where F — a fluid loss in cm 3 , Hu — the volume of erythrocytes on «not congestive» hand, Hq — the volume of erythrocytes on a «congestive» hand. Filtering of protein is determined by a difference of its contents (in grams on 100 cm 3 blood) in blood from veins of «congestive» and «not congestive» extremities taking into account a fluid loss.

At healthy faces during the carrying out L. the item quantity of a capillary filtrate does not exceed 4 cm 3 (on a nek-eye to data, to 5 cm 3 ), loss of protein does not happen absolutely or it does not exceed 0,1 g of %.

Pathological permeability of capillaries comes to light at L. the item increase in quantity of a filtrate and especially loss of protein, edge can reach 1 g of %. According to the researchers studying capillary permeability, L. the item, despite some shortcomings, has diagnostic advantages before other methods. In modern clinic the new methods of definition of permeability of capillaries based on use of radioisotopes in this connection L are applied and developed. item and Nesterova test (see) began to be used less often.

Bibliography: Landis E. M of Micro-injection studies of capillary blood pressure in human skin, Heart, v. 15, p. 209, 1930; o h e. Capillary pressure and capillary permeability, Physiol. Rev., v. 14, p. 404, 1934; it, Capillary permeability and the factors affecting the composition of capillary filtrate, in book: McMaster P. D. a. o. Lymph, p. 713, N. Y., 1946, bibliogr.

S. M. Kamenker.