From Big Medical Encyclopedia

LAKTOBAKTERIN dry (Lactobacterinum siccum) — the medicine consisting from lyophilized live laktobakterin (Lb. fermenti 90T — C4 or Lb. plantarum 8P — AZ), the dysenteric and enteropathogenic colibacilli which are actively suppressing life activity, pathogenic stafilokokk and a protea.

The principle of a bakterioterapiya and bakterioprofilaktika is proved by I. I. Mechnikov and directed to maintenance of normal microflora intestines (see), for the prevention and treatment of the diseases connected with disturbance of a natural biocenosis (see. Dysbacteriosis ).

Biomass of lactobacilli collects at deep cultivation on mediums which basis is hydras about a lysate of milk, malt extract or cabbage broth with additives of lactose or glucose at pH 6,2 — 6,5. Drug is stored at t ° 4 — 6 °, is good within a year from the moment of production.

Antagonistic activity of L. it is connected with action L-milk to - you (a strong antiseptic agent), the lactose accumulated by lactobacilli at fermentation and other sugars. Milk to - that transfers calcium of food to the calcium lactate acquired by an organism that promotes prevention of rickets at children. Laktobakterin participate in synthesis of vitamins, in the proteolysis with accumulation of easily acquired amino acids, including irreplaceable, not synthesized by a human body. The acid medium created by lactobacilli promotes development in intestines bifidobacteria (see).

L. favourably differs from bifidumbacterium (see) and kolibakterina (see) what can be applied along with antibiotics since the strains accepted for its production are steady against the most often applied antibiotics. Unlike bifidumbacterium which badly ferments milk, L. it is possible to use as ferment for receiving lactic products.

Inclusion of L. in a complex of therapeutic actions it is shown at acute intestinal infections, and also at the somatopathies demanding long courses of an antibioticotherapia or which are complicated by an intestinal dysbiosis.

LAKTOBAKTERIN is released in ampoules (1 — 3 doses), bottles (to 30 doses) or in tablets. One dose contains 4 — 6 billion living microbic cells.

Bibliography: Blochina I. N., Zhukova N. P. and F e r m and N of H. H. Experience of use in clinical nutrition of children of the drugs normalizing intestinal microflora and perspectives of their use, Pediatrics, No. 7, page 47, 1977; Bogdanov V. M. Microbiology of milk and dairy products, in book: Usp. mikrobiol., under the editorship of A. A. Imshenetsky, century 2, page 170, M., 1965; L of e of N of c of N of e r A. A. and That M. A ohm. A medium for cultivation of lactobacilli, Laborat, business, No. 10, page 616, 1964; R about g about s and M. a. Sharpe of M. E. of An approach to the classification of the lactobacilli, J. appl. Bact., v. 22, p. 329, 1959; S h a r p e M. E. Taxonomy of the lactobacilli, J. Dairy Sci. Abstr. v. 2 4, p. 109, 1962.

And. H. Blochina