From Big Medical Encyclopedia

KROSTI-DZHANOTTI DISEASE (A. Crosti, modern ital. dermatologist; F. Gianotti, modern ital. dermatologist; synonym: eruptive dermatitis of extremities at children, an acrodermatitis papular children, eruptive papular akrodermatoz, erythematous and papular akrodermatoz children, a lichenoid acrodermatitis of children) — ostrorazvivayushcheesya the disease which is characterized by a pyatnistouzelkovy enanthesis of extremities, a lymphadenopathy and is frequent damage of a liver. Dzhanotti in 1955 is described, and in 1957 Mr. Krosti and Dzhanotti gave more complete description of a disease.

Etiology it is not established. Toksiko-allergic genesis is supposed, some authors consider a disease a high-quality form of a reticulosis of skin.

Patogistologiya: acanthosis (see); in a derma limfogistiomonotsitarny infiltrate, the phenomena of a capillaritis (see. Vasculitis ).

A clinical picture

children up to 10 — 15 years Are ill preferential. It is characterized by flat or semi-spherical small knots symmetric to a reddish pasty consistence to dia, to 5 mm, located perifollikulyarno, it is frequent on an erythematic background (skin of extremities, preferential extensor surfaces, on a face). Rashes are accompanied by a lymphadenopathy. At a part of patients anicteric hepatitis, a splenomegaly is noted, are possible subfebrile fervescence, an adynamy, disturbances of activity went. - kish. a path, change from blood (a leukocytosis with a monocytosis and an eosinophilia).

Diagnosis put on a basis a wedge, and gistol, data. Differentiate with toxidermias (see), rubella (see), Letterer's disease — Siwa (see. to Letterera-Siwa disease ), inf. a mononucleosis (see. Mononucleosis infectious ), by red flat it is deprived (see. Deprive red flat ).

Treatment it is necessary in cases of damage of a liver; appoint polyneuramins 6 , In 12 , methionine.

Forecast. The disease lasts 2 — 8 weeks then usually passes often independently.

Bibliography: Arutyunov V. Ya. and about-lemba P. I. Gemotsermiya, page 154, M., 1964; B of N about I about in L., B I am a N about in B. and Dimitrov of Y. Klinik and a pathogeny of a syndrome of Dzhianotti — Krosti, Vestn, dermas, and veins., No. 2, page 14, 1963, bibliogr.; A dermatological sindromatologiya, under the editorship of R. S. Babayants, page 86, Yerevan, 1974; In of an u n - F and 1 with about O. u. Rupee of M. of tiber das Gianotti — Crosti-Syndrom, Acrodermatitis papulosa eruptiva infantilis, Med. Klin., S. 210, 1964; G r o s t i A. et Gianotti F. Dermatose eruptive acro-situee d’origine probablement viro-sique, Dermatologica (Basel), t. 115, p. 671, 1957; Gianotti F. Rilievi di una par-ticolare casistica tossinfettiva caratteri-zzata da eruzione eritemato-infiltrativa desquamativa a focolai lenticolari, sedc elettiva acroesposta, G. ital. Derm. Sif., v. 96, p. 678, 1955.

Yu. K. Skripkin.