From Big Medical Encyclopedia

INTERNAL ENVIRONMENT OF THE ORGANISM — set of the liquids (blood, a lymph, an intercellular lymph) washing cells, pericellular structures of the fabrics which are taking part in implementation of a metabolism of an organism. The term «internal environment of an organism» is offered by fr. scientific K. Bernard. Reactivity of bodies, their sensitivity to various influences, a trophicity, and also substantially a state and life activity of an organism in general depend on chemical structure, physical. - chemical and other properties of V.s.o.

Century of village of the lake is characterized by dynamic constancy (stability) that has special value for normal life activity of an organism (see. Homeostasis ).

The main V. of the village of the lake is blood (see), however the role of a direct medium of an organism (microenvironment) carries out fabric (intersticial, extracellular) liquid, structure and properties a cut are specific to separate bodies, correspond their structural and fiziol, to features (see. Intercellular lymph ). From a microenvironment of a cell receive necessary for their growth and food of substance and give products of metabolism to it. The chemical structure of an intercellular lymph is defined by intake of substances from blood, metabolism of fabric elements and transition of metabolic products to blood (clarification of an intercellular lymph). On structure it is close to a blood plasma, but contains much less protein. Receipt of components of an intercellular lymph from blood and the return outflow in a lymph and blood are regulated by selective permeability of gisto-gematichesky barriers (see. Barrier functions ). Defining composition of blood, an intercellular lymph and lymph (see), it is possible to judge the exchange processes happening in various bodies and fabrics and also a condition of an organism in general. The volume of an intercellular lymph at the person is on average equal to 26,5% of body weight. Some researchers carry to an intercellular lymph cerebrospinal liquid (see), liquid of an anterior chamber of an eye, joint (see. Synovial fluid ) and pleural liquid.

Bibliography: Kassil G. N. Blood-brain barrier, M., 1963, bibliogr.; Structure and function of gisto-gematichesky barriers, under the editorship of Ya. A. Rosina, M., 1971; Stern L. S. Direct medium of bodies and fabrics, M., 1960, bibliogr.; Brain barrier systems, Progr. Brain Res., v. 29, 1968; R u s z-nyak I., Foldi M. u. Szabo G. Physiologie und Pathologie des Lymphkreis-laufes, Budapest, 1957, Bibliogr.

Of H. Kassil.