From Big Medical Encyclopedia

INSULIN TEST (synonym: reaction to insulin, insulin test) — a diagnostic method of the endocrine diseases which are followed by disturbance of carbohydrate metabolism. Property of insulin to cause decrease in a sugar content in blood and sensitivity of an organism to insulin (see) is the cornerstone of test. To nominative it was offered by H. P. Himsworth in 1936.

Inspected on an empty stomach enter subcutaneously 0,2 or intravenously 0,1 PIECES of insulin on 1 t of body weight and in 20, 30, 45, 60, 90 and 120 min. after an injection define a sugar content in blood. Nominative is more specific if apply monocomponent insulin — drugs of insulin, free from glucagon (see). At suspicion on hypofunction of a front share of a hypophysis and bark of adrenal glands of Nominative carry out especially carefully in order to avoid hypoglycemic shock, at the same time the highest admissible dose of insulin makes 0,03 PIECES on 1 pg body weight.

At the healthy person in 20 — 45 min. after an injection of insulin the level of sugar in blood makes apprx. 50% initial, then increases and in 90 — 120 min. reaches an initial indicator or exceeds it.

At endocrine pathology observe two types of sugar curves. The first type shows resistance of an organism to insulin: after an injection the level of a glycemia does not change or changes slightly (less than 30%). Resistance to insulin is noted at acromegalias (see), Itsenko's diseases — Cushing (see. Itsenko — Cushing a disease ), Cushing's syndrome (see. Cushing syndrome ), thyrotoxicosis (see) and other diseases connected with hyperfunction of kontrinsulyarny hemadens (a front share of a hypophysis, cortical substance of adrenal glands, a thyroid gland). The second type of a sugar curve reflects high sensitivity to insulin and delay of reaction of an organism to a hypoglycemia: in 40 min. the level of a glycemia decreases by 50% and more and remains low within more than 2 — 3 hour.

High sensitivity to insulin is observed at pituitary cachexia (see), addisonovy disease (see), hypothyroidism (see), hyper dysinsulinism (see), etc.

At a diabetes mellitus (see. diabetes mellitus ) Nominative it is not specific, sensitivity to insulin at patients can be expressed, and in the presence of a syndrome of an insulinrezistentnost — is reduced or is absent.

Bibliography: Biochemical methods of a research in clinic, under the editorship of A. A. Pokrovsky, M., 1969; H i m s w o r t h H. Pt Diabetes mellitus, Lancet, v. 1, p. 127, 1936.

P. S. Zavadsky.