From Big Medical Encyclopedia

INDOPANUM (Indopanum; joint venture. A) — antidepressiviy means. alpha Metiltriptamina hydrochloride:

Crystal powder, white with yellowish shade, easily water soluble. And. excites the central and peripheral adrenoreaktivny systems, causes short-term reversible oppression of monoamine oxidase (MAO), exerts the stimulating impact on c. N of page.

And. apply as the stimulating and antidepressiviy cure for unsharply expressed depressions (circular psychosis, involutional and situational depression, affective fluctuations) and at borderline cases with affective disturbances (depression, slackness, apathy). And. it is also possible to apply at inertly current schizophrenia and during the periods of remissions at other forms of schizophrenia at patients with dominance of affective frustration (block, slackness, mental depression), but without the expressed productive symptomatology. Sometimes And. use as the proofreader at and the stenoapatichesky and astheno-depressive phenomena caused by aminazine and other neuroleptics.

Appoint And. inside, in the beginning 0,005 — 0,01 g (5 — 10 mg) 2 — 3 times a day, then increase a dose. Average daily dose of 0,02 — 0,04 g (20 — 40 mg). Decrease in a dose or drug withdrawal are made gradually. A maintenance dose — 5 mg a day. Duration of treatment is 60 — 80 days.

At reception And. excitement, sleeplessness, increase in the ABP, tachycardia, pains in heart, dermatitis is sometimes observed. In order to avoid frustration of a dream it is reasonable to accept drug only in the first half of day. And. it is impossible to apply along with other MAO inhibitors (it is necessary to take a break for 7 — 10 days). During 2 weeks after reception And. it is not recommended to appoint tricyclic antidepressants (an imipramine, amitriptyline, etc.). Drug is contraindicated at the agitated depression and depressive and paranoid states. It is necessary to be careful at appointment And. sick cerebral atherosclerosis and idiopathic hypertensia.

Form of release: tablets, coated, on 0,005 and 0,01 g. Keep in the place protected from light.

See also Antidepressants .

T. K. Trubitsyna.