From Big Medical Encyclopedia

INDOMETACIN (Indomethacinum; synonym: Indacin, Indocid, Indometacin, Inteban, Methindol, Metindol; joint venture. B) — non-narcotic analgesic. 1 (Para-chlorbenzoyl) - 5-metoksi-2-skatole-3-acetic acid, C 19 H 16 O 4 ClN:

Like other non-narcotic analgesics, And. has anesthetic, febrifugal and antiinflammatory effect. Surpasses salicylates and some derivatives of pyrazol in analgesic activity. Febrifugal action And. it is more expressed in comparison with derivatives salicylic to - you and pyrazyl ketone. In antiinflammatory action And. the principal value has its direct impact on inflammatory process (inhibition of synthesis of prostaglandins, reduction of permeability of vessels and migration of leukocytes, antagonism with mediators of an inflammation, antigialuronidazny effect, etc.). And., apparently, the hypophysis — bark of adrenal glands since its antiinflammatory action is expressed equally both at intact, and at adrenalectomized animals does not influence system.

And. it is well soaked up in went. - kish. path; in 4 hours after intake its maximum concentration in blood is created; it is brought out of an organism preferential through kidneys and partially through intestines.

And. apply at rheumatism, infectious nonspecific polyarthritis, arthroses, Bekhterev's disease, gout and other diseases. Appoint And. inside, in an initiation of treatment on 0,025 g 2 — 3 times a day (0,05 — 0,075 g a day), at good tolerance gradually increase a daily dose to 0,1 — 0,15 g. To stopping of bad attacks of gout apply 0,05 g 3 times a day, to prevention of attacks — on 0,025 g 2 times a day.

The main side effects observed at treatment And. — headaches, dizziness, drowsiness, confusion of consciousness, depressions, nausea, vomiting, anorexia, pains in epigastric area. And. possesses ulcerogenic action and can cause went. - kish. bleedings. For the prevention and reduction of the dispeptic phenomena it is recommended to appoint drug in time or after food in a combination with antiacid means, to wash down with milk.

And. it is contraindicated at cankers went. - kish. path. It is not necessary to appoint drug to pregnant women and the feeding women. And. appoint with care to the drivers of transport, persons working for machines, etc.

Forms of release: capsules and covered with a soluble cover of a tablet in intestines, containing 0,025 g of drug. Keep in the dry, protected from light place.

See also Analgesic means .

Bibliography: Agababova E. R. and Pavlenko T. M. Novy of antirheumatic! drug indometacin, Rubbed. arkh., t. 41, century 12, page 104, 1969; Milevskaya Yu. L. Use of indometacin in internal and hematologic clinic, in the same place, t. 42, century 1, page 80, 1970; Nasonova V. A., etc. Pharmakoteraprsh in rheumatology, page 74, M., 1976, bibliogr.; O'V of i e n W. M of Indomethacin, survey of clinical trials, Clin. Pharmacol. Ther., v. 9, p. 94, 1968, bibliogr.

V. K. Muratov.