From Big Medical Encyclopedia

HYDROGEN PEROXIDE (Hydrogenii peroxidum) — the inorganic chemical compound used in medicine as an antiseptic agent; H 2 O 2  ; pier. weight (weight) 34,01.

Depending on concentration affects bacteriostatically (0,2 — 0,3%) and bakteritsidno (0,5 — 3%) different types of microorganisms. In the same concentration renders the deodorizing effect. In high concentration (30% and more) possesses local irritative action and causes a depigmentation of skin and mucous membranes.

The mechanism of action

the Mechanism of action Is connected with the fact that at contact with fabrics under the influence of the enzyme which is contained in them catalases (see) P. century quickly decays with release of the molecular oxygen oxidizing various organic components of microbic cells. Vigorous release of oxygen at P.'s decomposition is followed by foaming of its solutions century. The foam which is formed at the same time promotes also mechanical clarification of wound surfaces since with it from wounds microorganisms are removed, particles of nekrotizirovanny fabrics, pus, etc. Besides, due to pricing solutions P. of century have the local styptic action at capillary bleedings caused by the fact that foam accelerates transition of fibrinogen to fibrin. Antimicrobic action of P. of century is short since release of oxygen comes from its solutions very quickly. On P.'s activity of century concedes to the drugs which are chipping off elementary oxygen, napr, to potassium permanganate (see. Potassium permanganate ).

Drugs of hydrogen peroxide

In medical practice use various drugs P. of century.

Penozone (Solutio Hydrogenii re-roxydi diluta; GFH) — the ofitsinalny solution containing in each 100 ml pergidrolya 10 g, the stabilizer (monoacetylaniline) of 0,05 g, water to 100 ml. P.'s maintenance century in solution — apprx. 3%.

Colorless, inodorous transparent liquid or with a slight peculiar smell, subacidic reaction. Quickly decays with release of oxygen on light, during the heating, contact with the oxidizing and deoxidizing substances, alkalis, nek-ry metals (iron, manganese, etc.).

Apply as the antiseptic and deodorizing means.

Appoint outwardly for washing of wounds and at ginekol, diseases, and also for rinsings at stomatitis and quinsy. As local styptic means is applied to a stop of capillary bleedings (e.g., nasal, after a tonsilectomy and others).

As directed GFH if «Solutio Hyd-Togenii peroxydi» is stated in the recipe and is not specified concentration, then release penozone in concentration of 3%; if penozone not of 3%, but other concentration is stated in the recipe, then it is produced cultivation pergidrolya or ofitsinalny solution P. of century water, proceeding from the actual maintenance of P. of century in initial drug.

Form of release: in bottles with the ground-in glass traffic jams. Keep in the cool, protected from light place.

The penozone concentrated (Solutio Hydrogenii peroxydi concentrata; synonym: perhydrol, Hyperol, Lapyrol, Perhydrolum, SP. B) — the solution containing 27,5 — 31% of P. of century.

An inodorous transparent colorless liquid or with a slight peculiar smell, subacidic reaction. Slowly decays at interaction with alkalis and organic matters.

In pure form, and also as a part of ointments apply as depigmenting means. Besides, use for receiving the solutions applied as antiseptic agents according to the same indications as ofitsinalny solution P. of century.

Form of release: in bottles with the ground-in glass traffic jams. Keep in the cool, protected from light place.

Hydroperitum (Hydroperitum; a synonym of Perhydrit) — complex connection P. of century with urea, CH 4 N 2 O-H 2 O 2 . Contains apprx. 35% of P. of century.

Release in the form of tablets of white color, easily water soluble. Water solutions have saltish and bitter taste.

Apply as an antiseptic agent instead of solutions P. of century. Before the use of a tablet dissolve in water at the rate of 1 tablet (mass of 1,5 g) on 15 ml of water (1 table, l.), what corresponds to 3% to solution P. of century. For rinsing of a mouth and a throat 1 tablet is dissolved in a glass of water that corresponds to 0,25% to solution P. of century.

Form of release: tablets on 1,5 g. Keep in densely corked packaging in the place protected from light at a temperature not over 20 °.

See also Antiseptic agents .

Occupational health by production of hydrogen peroxide

finds century for P. broad application not only in medicine, but also in various industries of the national economy (for whitening of materials of an animal and plant origin as an oxidizer for vat dyes and frother for receiving porous materials, for production of peroxidates and DR *).

P.'s production of century is carried out by hl. obr. using электро^ a chemical method through persulphuric to - that. Raw materials for P.'s production of century are 92 — 96% sulfuric to - that and distilled water. Technological process of receiving P. of century is carried out on a closed circuit (supply of raw materials, intermediate and end products almost entirely happens in the closed system of the equipment and communications).

The main factor which is negatively influencing health in P.'s production of century — pollution of the air environment of workrooms ozone and an aerosol a chamois to - you, especially those, in to-rykh is observed the combined influence of the specified substances (on sites of preparation of electrolyte, in electrolysis department, department of cleaning with a chamois to - you and hydrolysis persulphuric to - you); in these rooms it is necessary to determine the level of vapors P. of century in air. These couples define also in air of departments of neutralization and pouring. In conditions of production of P. of century harmful substances get to an organism in generally inhalation way. P.'s couples of of century get as well through integuments, having resorptive effect.

Getting to an organism, ozone, an aerosol a chamois to - you and P.'s couples of of century render local irritant action on mucous membranes of upper respiratory tracts and eyes. Expressiveness of symptoms of irritation depends on concentration of substances in air. The long contact (St. 5 years) with the specified professional vrednost can lead to development in workers hron, bronchitis of astmoidny character (see. Bronchitis ), followed by moderate emphysema (see), and initial phenomena pneumosclerosis (see). Also disorders of functions of c are possible. N of page like a neurotic syndrome with the expressed vegetative disturbances (see. Neurasthenia ), changes funkts, tests of a liver, development of anemias.

Preventive actions by P.'s production of century shall include use of hermetic filter press electrolyzers with aspiration of discharges, the shelter and aspiration of all open devices and tanks (tempering tanks, tanks, Nutsche filters, collections, etc.). Ventilation of production rooms shall be carried out with use of local suctions.

The century working in production with P. shall be provided with overalls from acid resisting material, gloves from polyvinyl chloride, polyethylene or polyester plastics, goggles or masks from transparent polymeric materials. Carrying out surveys preliminary and periodic (once a year) with participation of the therapist, neuropathologist and otorhinolaryngologist is obligatory.

Maximum allowable concentrations of ozone of 0,1 mg/m 3 , a chamois to - you are 1 mg/m 3 , P. century — 0,3 mg/m 3 .

Bibliography: Harmful substances in the industry, under the editorship of N. V. Lazarev and I. D. Gadaskina, t. 3, page 11, D., 1977; D and t of e r and x with D. D. and the Nevsky A. I. Occupational health in production of hydrogen peroxide by an electrochemical method, in book: Gigabyte. work in chemical prom-st, under the editorship of 3. A. Volkova, etc., page 386, M., 1967; Kondratov V. A. About comparative toxicity of vapors of hydrogen peroxide at inhalation and skin ways of influence, the Gigabyte. work and the prof. having got sick., No. 10, page 22, 1977; Mashkovsky M. D. Pharmaceuticals, p. 2, page 340, M., 1978; The pharmacological basis of therapeutics, ed. by L. S. Goodman a. A. Gilman, p. 997, N. Y. a. o., 1976.

V. K. Muratov; E. G. Dymova (gigabyte.).