From Big Medical Encyclopedia

HAGGINS Charlz (Huggins Charles Brenton, sort. in 1901) — the American surgeon-urologist, the member of National academy of Sciences of the USA, the Nobel Prize laureate (1966).

In 1927 ended Michigan un-t, worked as the surgeon-urologist. In 1929 — 1933 the associate professor, from 1933 to 1951 professor Chicago un-that. Since 1951 the director of oncological laboratory Chicago un-that.

The greatest scientific and practical value had experimental and clinical studying by Ch. Haggins of influence of hormones on activity of a prostate (see). In experiences on dogs it developed a quantitative method of assessment of function of a prostate by means of imposing of a fistula. Ch. Haggins established that introduction by an animal of male sex hormones strengthens function of a prostate whereas female sex hormones sharply reduce it. In 1941 it and his employees managed to show that administration of estrogen, especially in combination with castration, quite often leads to delay of growth of nek-ry tumors of a prostate, including and malignant. For these researches it was conferred the Nobel Prize on physiology and medicine.

Ch. Haggins developed also problems of hormonal therapy of a breast cancer, studied biochemistry of enzymes, interaction of fabrics during growth, selective effect of oncogenous substances on closed glands. It implemented in a wedge, practice a number of surgeries.

Ch. Haggins the honorary member of many surgical about - century

of Works: Studies on prostatic cancer, Cancer Res., v. 1, p. 293, 1941 (sovm. with

Hod ges of Page V.).

Bibliography: Vasilyev Yu. M. and

Samoylov V. I. Oncologists are Nobel Prize laureates of 1966, the Nature, No. 4, page 111, 1967; D a t t a R. To. a. D a t t and V. of Nobel prize winners in medicine, J. Indian med. Ass., v. 48, p. 41, 1967; Les prix Nobel en 1966, p. 106, 172, Stockholm, 1967.

A. V. Chaklin. AA. H. Podosinova.