GLYOXYLIC ACID

From Big Medical Encyclopedia

GLYOXYLIC ACID (glioksalevy acid) — the elementary half aldehyde; HCO-COOH. In an organism of animals and the person actively participates in amino-acid exchange; contains in unripe fruit, in process of their maturing disappears. Excess introduction of G. to. per os causes poisoning of an organism; poison works like substances foxgloves (see). Receive G. to. hydrolysis digaloidozameshchenny acetic to - t or recovery oxalic to - you. To. represents colourless prismatic crystals, t ° pl 98 °, well a rastvorima in water, it is bad — in alcohol, ether, benzene. With substances in which molecule there is an indole ring, G. to. forms a red-violet complex.

In vegetable and animal organisms of G. to. it is formed at oxidation glycolic to - you, deamination of glycine, from Tricarboxylic to - t of a citrate cycle. To. participates in interamination (see), forming glycine (see), and also in reaction of transacetylation with L-malate and KOA.

Assume that inborn metabolic disturbance, as a result to-rogo G. to. does not turn in the normal way, and as an end product of her metabolism it is formed oxalic to - that (oxalate), is the reason of primary hyperoxaluria (see. Oksaluriya ).


Bibliography: Kretovich V. L. Fundamentals of phytochemistry, M., 1971; M and r-dashev G. River and Syomina L. A. Euzymatic synthesis of glycine from glyoxylic acid, Dokl. Academy of Sciences of the USSR, t. 74, No. 3, page 537, 1950; Korn berg H. L. Anaplerotic sequences and their role in metabolism, in book: Essays in biochemi., ed, by P. N. Campbell a. G. D. Greville, v. 2, p. 1, L. — N. Y., 1966, bibliogr.

H.A. Pavlova.

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