GLYCOCYAMINE

From Big Medical Encyclopedia

GLYCOCYAMINE (guanildiglitsin) — guanidineacetic acid, C 3 H 7 O 2 N 3 , biochemical important connection, an intermediate product in a chain of transformations of ornithine to creatine. The product of phosphorylation of creatine — phosphocreatinine takes active part in the course of glycolysis in muscles.

For the first time G. was allocated from urine of the person by Weber (N. to Weber) in 1934 Mr.

Glikotsiamin we will dissolve in water, is almost not alcohol-soluble and ether; from water crystallizes in the form of leaflets, sometimes — needles. It is possible to synthesize from glycine of a hydrochloride and sodium cyanamide at presence konts. salt to - you; t°pl 270 — 280 ° (with decomposition).

In a human body and animal G. it is formed in kidneys and in a pancreas from arginine (see) and glycine (see) as a result of the reaction of a pereamidinirovaniye catalyzed by enzyme glycine-amidinotransferase (KF 2.1.4.1):

It is methylated in a liver at the expense of S-adenozil of methionine, forming creatine (see).

Definition of activity glycine-amidinotransferase in blood serum and in urine is used in clinic at differential diagnosis pancreatitis (see) and diagnosis of nephrites. Glycine-amidinotransferase in blood serum is not found in healthy people, and its emergence in it is treated as a signal of the beginning or developed necrosis of a pancreas; activity of enzyme reaches at the same time from 0,1 to 11 — 12 usl. units. At damages of kidneys enzyme appears in urine.


Bibliography Meister A. Biochemistry of the amino acids, v. 1 — 2, N. Y., 1965.

A. A. Dikanova.

Яндекс.Метрика