From Big Medical Encyclopedia

Clay in medicine, especially in surgery is widely applied. Adhesive strength depends on extent of sticking (adhesion) to adherend surfaces and forces of molecular coupling of an adhesive film and adherents (cohesion). To. happen liquid and firm, and depending on initial products — inorganic (solutions of Na or K silicate), organic (natural and synthetic polymers) and elementorganichesky (silicon - boron - organometallic polymers). To., applied to the medical purposes, shall stick together fabrics in the wet environment at body temperature; technology of pasting shall be easily feasible, rather bystry, visible (dullness of glue complicates orientation during the greasing of wound surfaces); To. shall not have toxicity, cause exothermic reaction (formation of heat with the phenomena of a burn), to interfere with natural accretion of fabrics. Products of metabolism and their conjugate, and also To. shall not be postponed for a long time in fabrics not to exert an adverse effect (Carcinogenicity, formation of foamy cells, necrotic effects, allergic reactions, etc.). To. shall be sterilized, keep easily elasticity of fabrics and not form the solid, rigid or brittle adhesive film interfering germination by its fabric.

These conditions are answered generally tsianakrilatny To., monomeric ethers alpha and cyanoacryl to - you which two elektronoaktseptorny groups cause extremely bystry and easy polymerization alkyl - alpha cyanoacrylates with formation of polymer under the influence of such mild bases as water and alcohol. A polymerization initiator is not only water, but also NH 2 - the group of amino acids, as causes strong sticking To. to living tissues. Gradually polyalkylcyanoacrylates are hydrolyzed that leads to their rassasyvaniye. With increase in an ester group of alkyl radical (methyl, ethyl, butyl etc.) sensitivity of living tissues to To. falls, their inflammatory reaction, speed of hydrolysis decreases and a little durability of an adhesive line decreases. On the basis of original synthesis monomeric alkyl (aryl) - alpha cyanoacrylates in the USSR glues are received: M-1, M-2, M-3, M-4, and also compositions of MK-2 and MK-6. Tsianakrilatnye K. is applied in experiments and in clinic as the basic and as supportive application for closing of wounds, in vascular surgery, in pulmonary surgery, in urology, neurosurgery, ophthalmology, orthopedics, traumatology, etc. (see. Seamless connection ). Shortcomings tsianakrilatny To. rather bystry polymerization, hardness and fragility of an adhesive film after polymerization is. From this point of view are more acceptable polyurethane (KL-2 and KL-3) and resorcin - gelatinous To. They form a porous elastic adhesive film, do not cause sharply expressed inflammatory reaction, however are difficult in use. Glue compound of fabrics on durability concedes to a usual surgical seam (with use of silk, capron, etc.).

Bibliography: Golovin G. V. Problem of pasting of bones, L., 1964, bibliogr.; Khromov B. M. Seamless compound (pasting) of fabrics and bodies at operations and damages, Owls. medical, No. 9, page 74, 1969; Shapiro of M. S. Tsianakrilatnye glues in traumatology and orthopedics, M., 1976, bibliogr.

K. S. Shadureky.