GIPPURAN (Hyppuranum) — contrast agent; sodium salt orthoiodbenzaminoacetic to - you:
Applied as contrast means for excretory Urografinum earlier. On the nature of kinetic processes of G. it is similar paraaminobenzaminoacetic to - those, used for definition of a renal blood-groove (see. Paraaminobenzaminoacetic test ). It is absorbed almost only by kidneys and quickly brought out of an organism with urine. After intravenous administration part G. contacts erythrocytes and blood proteins, this communication is easily reversible and does not exert noticeable impact on the speed of canalicular secretion; a part it is allocated by glomerular filtering. A ratio of clearance of G. and paraaminobenzaminoacetic to - you make 0,84 that allowed to use drug for definition of a renal blood-groove.
Apply marked G. to definition of function of kidneys (see. Kidneys, radio isotope research ). Directly after intravenous administration marked G. partially passes from a vascular bed into extracellular space. In process of decrease in concentration of G. in plasma and allocations its gradual return from extracellular space to blood comes his kidneys. The mechanism of allocation of G. is completely not studied by kidneys. It is considered that canalicular secretion has major importance, however it is necessary to consider also a possibility of glomerular filtering. It is confirmed by considerable similarity of dynamics of removal of G. and radioactive inulin.
See also Radiopaque substances .
H. N. Hodarev.