From Big Medical Encyclopedia

GERODERMA (gerodermia; Greek geron aged man + derma skin; synonym senile skin) — pathological premature involution of skin. Rummo and Ferranini (G. Rummo, A. Ferranini, 1897) — under the name «genitodistrofichesky geroderma» is described by the Bough and Sharko (A. Souques, J. Charcot, 1891) under the name «skin geromorfizm». It is observed at Verner's syndrome, Thomson's syndrome, Rotmund's syndrome (see. Verner syndrome , Poikiloderma , Rotmunda syndrome ).

In an etiology an important role is played by endocrine frustration (hypofunction of gonads, a hypophysis, etc.), genetic and, to a lesser extent, infectious factors. The pathogeny is not clear.

Patogistologiya: skin of an atrofichn, elastic fibers are kept only in a superficial part of a derma.

The first wedge, symptoms Appear usually already at children's age, is more rare in the period of puberty. Skin becomes thin, dry, smooth, brownish color. Turgor of skin sharply decreases, skin is easily displaced, hanging folds with deep furrows, almost without hypodermic cellulose, easily ulcerates; secondary pilosis is absent. At the main, genitodistrofichesky, a form the hypoplasia of gonads is noted, patients are infantile, dystrophic. Allocate also atipichesky forms G.: pseudo-acromegalic, pseudo-myxedematous and a form with the phenomena of feminism. G.'s combination to dwarfish growth and adiposogenital dystrophy, to not diabetes mellitus and other endocrinopathies is described (obesity, Simmonds's disease, etc.).

Diagnosis put on the basis a wedge, and patogistol. pictures. There are no effective methods of treatment. Changes of skin are irreversible.