From Big Medical Encyclopedia

GANGLIONIC SUBSTANCES — the substances influencing preferential synoptic transfer of nervous impulses in vegetative gangliya.

To belong gangliostimuliruyushchy and ganglioblokiruyushchy means (see).

The basic group of the substances stimulating a ganglion is made by so-called N cholinomimetics (see. Cholinomimetic substances ).

Gangliostimuliruyushchy substances excite N-holinoreaktivnye of structure gangliyev, and also a sinocarotid zone and marrow of adrenal glands.

On a chemical structure gangliostimuliruyushchy substances divide into the following groups: 1) monoonium compounds — tetramethyl-ammonium (TMA), 1,1-dimethyl-4-fenilpiperaziny iodide (DMRR); 2) bischetvertichny ammonium connections — Subecholinum (see); 3) basic nitriles — nicotine (see) and lobeline {see); 4) secondary amino — cytisine (see. Cytitonum ).

Some N cholinomimetics (lobeline and cytisine) apply as stimulators of breath. Excitement of a respiratory center happens reflex to N-holinoretseptorov of a carotid sine.

Bibliography: Harkevich D. A. Ganglionic means, M., 1962, bibliogr.; Volle R. L. Muscarinic and nicotinic stimulant actions at autonomic ganglia, in book: Int. Encyclopedia Pharm. Therapeutics, ed. by A. G. Karczmar, Sect. 12, v. 1, Oxford a. o., 1966,

D. A. Harkevich.