From Big Medical Encyclopedia

GANGLERONUM (Gangleronum; synonym Ganglefeni hydrochloridum; GFH, joint venture. B) — antispasmodic;

Z-Dietilamino - 1,2-dimethylpropyl ether p-izobutoksibenzoynoy to - you are a hydrochloride, C 20 H 33 NO 3 • HCl:

White crystal powder, we will easily dissolve in water and alcohol, it is hygroscopic.

Has cholinolytic and spasmolytic effect (causes relaxation of smooth muscles and expansion of blood vessels; blocks nikotinchuvstvitelny cholinereactive si-systems vegetative gangliyev and c. the N of page), has mestnoanesteziruyushchy properties. Unlike other esters of carboxylic acids — Spasmolytinum (see), aprophene (see), Tifenum (see), G. does not influence muskarinovy effects of acetylcholine.

Apply hl. obr. for the prevention of attacks of stenocardia. At averages and severe forms of a disease drug is appointed by 4 times a day according to the following scheme: the first two days on 1 ml, for the third and fourth day on 2 ml, from the fifth to the ninth day on 3 ml of 1,5% of solution intramusculary or subcutaneously; from the 10th day replace one injection with intake (to food) on 1 chayn. l. 1,5% of solution of the drug divorced in 50 — 75 ml of water; within four days completely pass to administration of drug inside. Apply G. also in tablets on 0,04 g four times a day. The general duration of treatment — 4 — 5 weeks the Highest doses for adults inside: one-time — 0,075 g, daily — 0,3 g; under skin and intramusculary: one-time — 0,06 g (4 ml of 1,5% of solution), daily — 0,18 g (12 ml of 1,5% of solution).

It is usually well transferred by patients. In concentration higher than 1,5% it is impossible to use drug for injections since it can cause irritation and a necrosis of fabrics.

Forms of release: 1,5% solution in ampoules on 2 ml in bottles on 100 ml for intake, tablets and capsules on 0,04 g

See also Antispasmodics .

Bibliography: Gangleronum and experience of its clinical use, under the editorship of. A. L. Mndzho-yana, Yerevan, 1959; Davidov-Sky H. M. Gangleron, Yerevan, 1967.

O. M. Avakyan.