GALANTAMINUM (Galanthaminum) — the antikholinesterazny means raising a tone of unstriated muscles; the alkaloid emitted from bulbs of a snowdrop of Galanthus woronowu, this. amarillisovy (Amaryllidaceae).
In medical practice apply hydrobromide of Galantaminum (Galanthamini hydrobromidum; synonym: Galanthaminum hydrobromicum, Nivalinum, Nivalinum; GF OF X, joint venture. A), C 17 H 21 NO 3 • HBr:
White fine-crystalline powder of bitter taste. Let's difficult dissolve in water, it is almost insoluble in alcohol. Aqueous solutions (pH = 5,0 — 7,0) will sterilize at t ° 100 ° within 30 min.
On pharmakol, drug is close to properties to to physostigmine (see), but is less toxic. Activity of true and false cholinesterase oppresses, raises a tone of smooth muscles of internals, narrows a pupil, slows down cordial activity, strengthens salivation, stimulates neuromuscular transmission, is an antagonist of tubocurarine and kurarepodobny substances of competitive type of action. Gets through a blood-brain barrier, in the corresponding doses facilitates carrying out impulses in synapses of c. the N of page also strengthens processes of excitement. Peripheral muskarinopodobny effects of G. are removed cholinolytic substances (e.g., atropine), nicotinosimilar — kurarepodobny and ganglioblokiruyushchy substances.
Apply At the myasthenia, a myopathy, the residual phenomena of poliomyelitis, sensitive and motive disturbances connected with diseases and traumatic damages of a nervous system; at an atony of intestines and bladder; for functional diagnosis at rentgenol, a research of a stomach.
Hydrobromide G. is entered under skin in the form of aqueous solution once daily or every other day, and if necessary — two times a day. A single dose for adults — 0,0025 — 0,01 and (0,25 — 1 ml of 1% of solution). The highest doses for adults: one-time — 0,01 g; daily — 0,02g. The term of treatment depends on efficiency of drug and the nature of a disease. During the recovery and residual periods of acute front poliomyelitis the course of treatment consists of 10 — 20 injections made 2 — 3 times a week. G.'s introduction is recommended to be combined with physical. by methods of treatment. As the antagonist of kurarepodobny substances G. enter into a vein in a dose of 0,015 — 0,025
usually well it is transferred by patients. At overdose and hypersensitivity to drug by-effects can be observed: bradycardia, hypersalivation, dizziness, etc. At the expressed by-effects enter under skin or into a vein atropine (1 ml of 0,1% of solution).
it is contraindicated at epilepsy, hyperkinesias, bronchial asthma, stenocardia, bradycardia.
Forms of release: powder; 0,1%, 0,25%, 0,5% and 1% solutions in ampoules on 1 ml.
See also Antikholinesterazny means .
M. D. Mashkovsky.