FUCHSINOPHIL DEGENERATION

From Big Medical Encyclopedia

FUKSINOFYLNY DEGENERATION (+ Greek phileo to love fuchsin; degeneration; a synonym acidophilic dystrophy) — the damage of cardiomyocytes which is coming to light at microscopic examination by means of coloring by magenta acid.

The term is offered G. Selje in the 50th: are 20 century old for designation of early: forms of metabolic damages of the cardiomyocytes found after a preliminary protravlivaniye gistol. cuts phosphatotungstic to - that and coloring by their fuchsin (see).

T. meets at intoxications of various origin, disturbances of hormonal and electrolytic exchange, the raised muscular exercise, a hypoxia of various genesis, inflammatory and immune disturbances. T. is more often observed at the proteinaceous dystrophies (see. Proteinaceous dystrophy) which are coming to an end with a coagulative necrosis (see).

At the heart of F. lie changes physical. - chemical properties of cytoplasm and organellas of cardiomyocytes, causing their affinity to acid dyes. Ability of the damaged cardiomyocytes to perceive fuchsin is connected with emergence in them as a result of a denaturation of proteins of free radicals (see Radicals free).

Comparison of coloring on the Selye with other gistol. by methods of a research demonstrates that its results are not constant, and degree of a fuchsinophilia not always authentically reflects weight of damage of cardiomyocytes. In a crust, time for morfol. diagnoses of damages of cardiomyocytes use CHIC reaction (see), coloring across Mallori more often (see Mallori methods), and also polarization microscopy (see. Microscopic methods of a research) and luminescent microscopy (see).

Bibliography: / Danilova K. M, About essence experimental adrenalinic - myocarditis, Arkh. patol., t. 23, No. 11,

page 11, 1961; R at to about with at e in V. S. O to the nature of a fuchsinophil degeneration myshech-

ny fibers, in the same place, t. 26, No. 5, page 38, 1964; Xie of league of. Prevention of necroses of heart chemical means, the lane with English, M., 1961; Semenova L. A. About the nature of a so-called fuchsinophil degeneration of a myocardium, Arkh. patol., t. 33, No. 1, page 24, 1971; Serov R. A. and d river. Use of coloring by hematoxylin — the main fuchsin — picric acid — (GOFP) for identification of injuries of a myocardium of various genesis, in the same place, t. 39, No. 5, page 70, 1977; L i e J. T. and. lake of New histochemical method for morphologic diagnosis of early stages of myocardial ischemia, Proc. Mayo Clin., v. 46, p. 319, 1971. And. E. Galankina.

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