FTOROTANUM (Phthorothamim; synonym: Fluothane, Ftorotan, Halothane, Na-lot of hanum, Narcotan, etc.; GFH of the joint venture. B) — means for an inhalation anesthesia. 1, 1, 1-trifluoro-2-chlorine-2-brometan; C2HBrClF3:
The drug used for an anesthesia is mix right-and laevoisomers F.
Transparent, colourless, mobile, easily volatile liquid with the smell reminding chloroform, sweet and burning taste does not ignite. We will dissolve in water a little, density 1,865 — 1,870, a pier mixes up with anhydrous alcohol, ether, chloroform and trichloroethylene, * °kip 49 — 51 °. weight (weight) 197,43. Couple F. in mix with air and oxygen are not explosive. Under the influence of light decays with education flying to - t, including poisonous hydrobromic to - you. For stabilization F. add up to 0,01% of methyl-isopropyl phenol to it. T. does not decay alkalis therefore it can be used in narcotic devices with a chemical absorber of carbon dioxide gas.
Pressure of vapors F. over liquid very high (at f 20 ° 241.5 mm of mercury are equal.). We will dissolve in blood and intercellular lymphs a little, we will easily dissolve in lipids.
The main amount of drug is distinguished from an organism in not changed look, very small part is metabolized. At inhalation 2 — 4 about % of Ftorotanum quickly there comes the anesthesia. Depth of an anesthesia and its current depend on concentration of drug in blood. The surgical grade of anesthesia is supported by inhalation 1 — 2 about % of Ftorotanum.
T. poorly suppresses nociceptive (painful) irritations that should be considered during the carrying out under this anesthesia of operative measures and painful manipulations. T. well relaxes skeletal muscles that allows to use a ftorotanovy anesthesia even at abdominal organs operations. However for these purposes it is better to combine more superficial anesthesia with introduction of muscular relaxants (see Muscle relaxants). Couple F. do not irritate a mucous membrane of bronchial tubes and pulmonary fabric therefore it can be used for an anesthesia at diseases of lungs, including at patients with bronchial asthma. External respiration oppresses in proportion to depth of an anesthesia.
The Ftorotanovy anesthesia is followed by delay of pulse and decrease in the ABP due to reduction of peripheric resistance of vessels and cordial emission. T. increases sensitivity of heart to catecholamines (see) in this connection use of adrenaline and other catecholamines against the background of a ftorotanovy anesthesia can lead to development of arrhythmias. For this reason it is impossible to use F. for anesthesia at patients with a pheochromocytoma and at other states connected
with a giperkatekholaminemiya. For fight against falling of the ABP at an anesthesia F. it is impossible to apply adrenaline and noradrenaline before release of drug from an organism. Ftorotanum negatively affects the affected liver.
There are data on mutagen properties F. and abilities of this drug to cause allergic reactions at repeated influence, in particular in medical staff.
Use of Ftorotanum in anesthesiology. T. use both for introduction, and for the main anesthesia (see) almost in all fields of surgery.
In combination with muscle relaxants F. widely use at the combined endotracheal anesthesia with artificial ventilation of the lungs at lung, abdominal organs operations, in urology, traumatology and orthopedics. It is applied also at operations with use of artificial circulation (see).
Indispensable condition of carrying out anesthesia F. — existence of precisely dosing evaporator, raspolozhe*i-ny out of a circulating system of gas-narcotic mix. In special situations F. it is possible to apply a thaw - but on Esmarkh's mask.
In connection with weak analgetic properties F. the stage of an analgesia at an introduction ftorotanovy anesthesia is not observed. The stage of excitement is absent or is short-term. The surgical grade of anesthesia comes in 3 — 7 min. from the beginning of inhalation.
After interruption in supply F. quickly there comes awakening and recovery of painful sensitivity. Awakening quite often is followed by a fever, to-ry is stopped by non-narcotic analgesics and warming of the patient. Nausea and vomiting usually are not observed.
T. it is reasonable to use as addition to an anesthesia with nitrous oxide in a flow of oxygen for an introduction and main anesthesia at children and in out-patient practice, maintenance of an anesthesia with the kept independent breath at short-term operative measures.
At an anesthesia F. it is necessary to reduce on x / z — D°3U the anti-depolarizing muscle relaxants. During the carrying out the managed hypotension (see Hypotonia artificial) F. it is reasonable to apply Ganges-lioblokiruyushchikh of means with the doses reduced half.
T. it can be applied in mix with other inhalation anesthetics, napr, by ether. Constant boiling mixture of Ftorotanum and ether is prepared by ex tempore (see. Inhalation anesthesia). Prodolzhitel
a nost of an introduction anesthesia at use of this mix is longer, than at use F. This mix is used as addition to an anesthesia with nitrous oxide for the same indications, as F.
Ftorotanovy an anesthesia is contraindicated in the first half of pregnancy and at patients with damage of a liver. It is undesirable to use it at patients with the increased intracranial pressure. In need of such cases take measures to pressure decrease of cerebrospinal liquid in the beginning and carry out an anesthesia F. against the background of artificial ventilation of the lungs (see. Artificial respiration). Use F. at childbirth it is dangerous since at the same time sensitivity of a uterus to oxytocin decreases and profuse uterine bleedings are possible.
Form of release: in well corked bottles of orange glass on 50 ml. Storage: in the dry, cool, protected from light place. After 6 months of storage is subject to check on purity.
Bibliography: Manevich A. 3. and Altshuler R. A. Ftorotanovy (flyuota-new) anesthesia, M., 1966; The Guide to anesthesiology, under the editorship of T. M. Darbinya-n, M., 1973; Raventos J. The action of fluothane, new volatile anesthetic, Brit. J. Pharmacol., v. 11, p. 394, 1956; Smith G. Halothane in clinical practice, Brit. J. Anaesth., v. 53, suppi. 1, p. 17S, 1981. A. 3. Manevich.