FTIVAZYD (Phthivazidum; synonym: Ftivazidum, Vanicide, Vanillaberon, Vanizide; joint venture. B) — an antituberculous remedy of group of hydrazide isonicotinic to - you are (GINK). Izoni-kotinoil-(3-metoks - 4 oxybenzal) hydrazone, or Z-metoksi-4-oksi-benzilidengidrazid isonicotinic to - you; C14H13NoC3 * H20:
Light yellow fine-crystalline powder with a smell of vanillin, low solubility in water and alcohol, it is good — in inorganic acids and alkalis. T. possesses the expressed tuberculostatic action conceding, however, to an isoniazid (see). Selectively slows down growth of mycobacteria of tuberculosis of preferential human look. In comparison with an isoniazid F. it is more slowly and not completely soaked up from went. - kish. a path, the maximum concentration in blood is created in 2 — 3 hours. Drug is removed from an organism of hl. obr. kidneys, partially through went. - kish. path.
On therapeutic action F. more weakly than an isoniazid, but is less toxic. It is applied to treatment of all forms and localizations of active tuberculosis in cases of bad portability of an isoniazid.
Appoint inside after food 0,5 g 2 — 3 times a day. Average daily doses for adults of 1 — 1,5 g, for persons are more senior than 60 years — i of the Highest doses for adults inside: one-time 1 g, daily 2 g. To children appoint at the rate of 0,03 — 0,04 g/kg a day (no more than 1,5 g). Dose
F. it is possible to increase at heavy processes, and also the patient, at to-rykh quickly there comes the inactivation of GINK in this connection the single dose of all daily dose is recommended.
For prevention of development of medicinal stability of mycobacteria (see. Medicinal stability of microorganisms) and strengthenings of therapeutic action F. apply in combinations with other antituberculous remedies, except drugs of the GINK group.
T. it is contraindicated at epilepsy, an ischemic disease and dekom-pensirovanny heart diseases, in the next weeks after the postponed myocardial infarction, at diseases central and peripheral nervous systems, a liver and kidneys (not tubercular etiology) with disturbances of their functions.
T. it is usually well transferred; the side effects similar the isoniazid observed at treatment are possible, however, (a headache, dizziness, paresthesias, deterioration in a dream, a heartache, etc.) - For prevention and weakening of neurotoxic action F. appoint a pyridoxine, thiamin, glutaminic to - that, ATP.
Form of release: powder, tab
letka on 0,1; 0,3 and 0,5 g.
Storage: in well corked container.
See also Antituberculous remedies, Tuberculosis, philosophy of treatment.
Bibliogrrabukhin A. E. Chemotherapy of TB patients, M., 1970.,
V. V. Utkin.