FTALAZOLUM (Phthalazolum; synonym: Enterozol, Sulfathalidine, Taleudron, Talidine, Talisulfazol, etc.; GFH, joint venture. B) — antibacterial agent from group of sulfanamide drugs. 2 (Para-fta-lilaminobenzolsulfamido) - thiazol; Ci7H1305N3S2:
Crystal powder, white or white with a yellowish shade, almost not water soluble, we will dissolve in water solutions of weak alkalis.
T. belongs to badly soaking up from went. - kish. path to sulfanamide drugs. At intake is exposed to slow hydrolytic decomposition in a small bowel with release of free Norsulfazolum (see; to-ry collects in a large intestine in high concentration and has antibacterial effect on the microflora which is contained in it. Formed from F. Norsulfazolum is soaked up in blood in very low concentrations and quickly brought out of an organism. In this regard it has practically no resorptive effect.
T. apply inside to treatment of bacterial dysentery (see) and coloenterites (с^м. Enteritis). At acute dysentery in the first 2 days of treatment F. appoint the adult on
1 g each 4 hours, in the next
2 days on 1 g each 6 hours, then within 3 — 4 days on 1 g every the 8th hour. In total on a course of treatment of a nazn< about 25 — 30 g of drug hope.
At coloenterites F. each 4 — 6 hours within 2 — 3 days appoint 1 — 2 g to reception. Then the daily dose is reduced twice. To children up to 3 years F. appoint in doses 0,1 — 0,2 g/kg a day, to-ruyu give in three steps. To children 3 years F are more senior. appoint 0,4 — 0,75 g to reception 4 times a day. Course of treatment of 7 days. According to indications treatment of dysentery and coloenterites can be carried out combining appointment F. with antibiotics or derivatives of nitrofuran.
The highest doses for adults: one-time 2 g, daily 7 g.
As side effects F. can cause dispeptic frustration, allergic reactions, a headache, a leukopenia. Contraindication to appointment F. existence in the anamnesis of allergic reactions to sulfanamide drugs is.
Form of release: tablets on 0,5 g. Storage: in the dry, protected from light place.
See also Sulfanamide drugs. E. N. Padeyskaya.