From Big Medical Encyclopedia

FRIEDMAN REACTION (M. of II.Friedman, amer. physiologist, sort. in

1903) — a diagnostic method of pregnancy in early terms. Reaction is offered in 1929 by Friedman.

It is based on emergence in urine of pregnant women chorion of an ichesky gonadotrophin (see). T. rubles — a biological response, to-ruyu will see off on puberal doe-rabbits at the age of

3 — 5 months, is powerful (weighing) from 900 to 1500 g. Within a day enter 4 ml of the sterile urine taken from the inspected woman into an ear vein of a doe-rabbit of 6 times. In 48 — 72 hours after the last injection to a doe-rabbit make a chrevosecheniye. In the presence at the inspected woman of pregnancy at a doe-rabbit characteristic changes in ovaries and a uterus are observed: increase and a considerable hyperemia of ovaries, hemorrhages in follicles or development of yellow bodies, and also puffiness and increase in a uterus. The last, however, are not specific and do not prove existence of pregnancy. Microscopic examination of ovaries is not required since all changes are well visible with the naked eye.


In a crust, time F. ruble lost the value in connection with broad use immunol. diagnostic methods of pregnancy, advantage to-rykh is high specificity, speed and relative simplicity of performance.

Bibliography: Largely A. Ya. Gormo

nalny diagnostic methods of pregnancy, page 43, JI., 1956; Makarov R. R. Extrauterine pregnancy, page 90, JI., 1958; The Reference book on obstetrics and gynecology, under the editorship of L. S. Persianinov and I. V. Ilyin, page 324, L., 1980; Friedman M. H. Mechanism of ovulation in rabbit, ovulation produced by injection of urin from pregnant women, Amer. J. Physiol., v. 90, p. 617, 1929.

I. P. Zhendrinsky.