From Big Medical Encyclopedia

FOX — FORDYCE a disease

(G. H. Fox, an amer. dermatologist, 1846 — 1937; J. A. Fordyce, amer. the dermatologist, 1858 — 1925) — the rare chronic disease of skin caused by dysfunction of sweat (apocrine) glands.

For the first time the disease is described in 1902 by Fox and Fordyce. Female persons at the age of 13 — 35 years are ill preferential, separate cases at men are described. Dysfunction of apocrine glands (see Sweat glands), apparently, is connected e by dysfunction of gonads

what exacerbations of a disease before periods, spontaneous recovery after approach of a menopause indirectly testify to and in some cases during pregnancy, therapeutic effect of the means oppressing an ovulation, etc.

At gistol. a research in epidermis the hyperkeratosis (see) which is most expressed in mouths of hair follicles and an acanthosis is noted (see); in a papillary layer of a derma perivascular, preferential lymphocytic infiltration comes to light. Apocrine glands are not changed or surrounded and penetrated by inflammatory infiltrate.

The wedge, a picture is usually characterized by symmetric damage of skin axillary vpadyan, quite often areas of nipples and generative organs, is more rare — a navel, a pubis, a crotch, inner surfaces of hips where there are papules (see); they have rounded conical shape, are located in mouths of hair follicles, are often grouped in the plaques which are not merging among themselves have light brown, pinkish color or color of normal skin, plotnovaty to the touch, their size to 5 mm in the diameter. Coloring of skin on affected areas is not changed, sometimes skin is slightly pigmented, hair dim thinned or are absent, sweating is strengthened. Patients are disturbed by the painful itch amplifying during periods. Course of a disease chronic.

The diagnosis is established on the basis by a wedge, pictures, in doubtful cases it is confirmed gistol. research of skin. Differential diagnosis is carried out with neurodermatitis (see) and multiple gidradenomy apocrine glands — the rare benign tumor developing in the form of small small knots from secretory department of apocrine glands (see Sweat glands, tumors).

Treatment is carried out by means, corrective by dysfunctions of generative organs; locally appoint electrothermic coagulation of small knots (see Diathermocoagulation), a roentgenotherapy (see), wipings spirit solutions of antipruritic means, ointments with glucocorticosteroids; washing with hexachlorofoehn soap is shown. Sometimes excise affected areas of skin with the subsequent transplantation.

Forecast favorable.

Bibliography: Differential diagnosis of skin diseases, under the editorship of. A. A. Stud-nitsina, page 143, M., 1983; JI e in e r U. F. Gistopatologiya of skin, the lane with English, page 139,

M., 1958; Fox G. N

of a. Fordy ce J. A. Two cases of a rare papular disease affecting the axillary region, J. cutan. gen. - urin. Dis., v. 20, p. 1, 1902; G e r t 1 e r W. Systematische Dermato-logie und Grenzgebiete, Bd 1, S. 615, Lpz., 1970; Kronthal H. L.,

Pome-r a n z J.

R. a. S i t o m e r G. Fox— Fordyce disease, Arch. Derm., v. 91, p. 243, 1965. And. M. Raznatoveky.