From Big Medical Encyclopedia


(A. Vogt, the Swiss ophthalmologist, 1879 — 1943; Y. Koyanagi, Japanese ophthalmologist, sort. in 1889; synonym: neyrodermatouveit, a uveoku-tanny syndrome, Harada's disease, a syndrome of Koyanagi) — the symptom complex of an unknown etiology including damage of eyes (uveitis), skin and a hair (vitiligo, canities, baldness), and also an inner ear (dysacusis).

The syndrome is for the first time described by Vogt in 1906. There are virus, allergic and endocrine (pituitary and thalamic frustration) theories of an origin of a syndrome.

In the initial (meningeal) stage headaches, vomiting, fervescence, a nek-swarm decrease in sight with the phenomena of a papilledema are noted. Usually in 15 — 30 days after the beginning of a disease the main symptom F develops. — To. page — acute or hron. the bilateral uveitis (see), to-ry can be complicated by amotio of a retina (see), a phacoscotasmus (see the Crystalline lens), glaucoma (see) — the ophthalmologic

period. Damage of eyes in half of cases is followed by relative deafness (see) with hypersensitivity to high-pitch tones. Further usually against the background of regress of a uveitis canities of eyelashes and hair on certain sites of the head, baldness (see the Alopecia) and symmetrized (it is preferential on brushes) sites of vitiligo come to light (see).

The diagnosis is established on the basis by a wedge, pictures.

Treatment is carried out by AKTG, corticosteroids, antiviral means (see); locally appoint corticosteroid ointments, in eyes — mydriatic means (see).

The forecast for life favorable; sometimes all symptoms pass in several months.

Prevention is not developed. Bibliography: A dermatological sindromo-logiya, under the editorship of R. S. Babayants, page 236, Yerevan, 1974; Koyanagi J. Dysaku-sis, Alopecia und Poliosis bei schwerer Uveitis nicht traumatischen Ursprungs, Klin. Mbl. Augenheilk., Bd 82, S. 194, 1929; Vogt A. Fruhzeitiges Ergrauen sogenannten plotzlichen Eintritt dieser Ve-randerung, ibid., Bd 45, S. 228, 1906.

S. S. Kryazheva.