From Big Medical Encyclopedia

FLORIMITsYN (Florimycimim; a synonym biomycin) — the reserve antitubercular antibiotic produced by Streptomyces floridae. T. treats group of cyclopeptides, it is applied in the form of a florimi-tsin of sulfate. Total formula of a florimitsin C23H36N12 08, pier. weight (weight) 608,6.

Crystal substance of pale yellow color, we will well dissolve in water at pH 5,6 — 7,8. Water solution of a florimitsin is stable at f 24 ° during 7 days Florimitsin suppresses synthesis of protein of a microbic cell, selectively acts on a mycobacterium of tuberculosis (bacteriostatically in a stage of proliferation), however on expressiveness of effect concedes to streptomycin (see) and to rifampicin (see Rifamycinums). Minimum overwhelming concentration F. for mycobacteria of tuberculosis fluctuate over a wide range on various mediums; also essential fluctuations in sensitivity to an antibiotic at different types of mycobacteria are observed. On other species of microorganisms F. in the concentration reached in an organism does not work.

Concentration F are necessary for suppression of intracellularly located mycobacteria of tuberculosis., it is considerable (to 100 times) exceeding therapeutic, the located activators operating on vnekletochno. For a mycobacterium of tuberculosis, steady to F., incomplete cross streptomycin resistance and Kanamycinum is characteristic (see). To the actor yole. the indication for appointment F. resistance of mycobacteria of tuberculosis to the fixed antituberculous remedies serves. T. it is soaked up only at parenteral administration. After intramuscular introduction it is quickly soaked up and during 4 — 8 hours it is found in blood in high concentration, T. it is allocated with kidneys by glomerular filtering, concentration of an antibiotic in urine reaches 1000 mkg/ml.


Use of a florimitsin in clinic is issued in bottles for injections on 0,5 and 1 g of FLURANS. Drug is used as reserve at the combined chemotherapy of patients with various forms and with various localization of tuberculosis (see), at to-rykh use of the fixed antituberculous remedies is inexpedient because of development of stability to them of the activator or their bad portability. It is preferential appointed in the expressed exudative phase of a tubercular inflammation.

It is entered intramusculary and int-ratrakheobronkhialno, including in the form of aerosols. Maximum one-time and average daily doses for adults make 1 g. The maximum daily dose — 2 g. Doses for patients with a weight (weighing) body less than 50 kg and persons are more senior than 60 years do not exceed 0,75 g a day. Daily doses for children and teenagers define at the rate of 15 — 20 mg on

1 kg of body weight (but no more than 0,5 g to children and 0,75 g to teenagers). The daily dose is usually entered for once, but for improvement of portability it can be divided for double introduction. Duration of treatment is defined by the course of a disease (usually 3 months and more). The drug is administered daily with an obligatory break every 7th day. At bad portability various schemes of Monday-termittiruyushchego of use can be used.

Complications are connected with neurotoxic, ototoksichesky and - nephrotoxic action of F. Opisana of disturbance of electrolytic balance, shown muscular weakness, spasms, etc. Allergic reactions are possible. T. it should not be applied at the same time with streptomycin, Kanamycinum, Monomycinum (see), gentamycin (see), Ristomycinum, (see) and Neomycinum (see) in connection with the similar nature of toxicity, and also it should not be applied together with furosemide (see) and kurarepodobny-m means (see Kurarepodobny substances). Contraindications to use F. same, as for Kanamycinum. To pregnant women and children up to 13 years F. it can be appointed only according to vital indications.

Bibliography: N and in and sh and S. M. N and F ohms of ii of N and I. P. Rational antibioticotherapia, page 278, M., 1982; Proti

votuberkulezny drugs, under the editorship of

N. A. Shmelyov, M., 1969; Tuberculosis

of a respiratory organs, under the editorship of A. G. Homenko, page 560, M., 1981.

S. M. Navashin; G. A. Korotayev (wedge.).