From Big Medical Encyclopedia

EZOFILAKSYYa (Greek eiso inside, inside + phylaxis protection, protection; snn. an ekfilaksiya) — the protective properties of skin which are shown at various pathogenic impacts of the environment on an organism.

The term «ezofilaksiya» was offered by E. Goffmann in 1919; it also used N. F. Gamaley (1928) by consideration of a problem of local immunity. According to E. Goffmann (1930), protective properties of skin are caused not only the fact that it provides mechanical protection of a body of the person and animals, but also its ability to send the nervous and humoral signals increasing resistance of an organism to action of various disturbing factors in an organism.

Representation about E. arose and developed from observations that various patol. processes are localized in skin and in internals in opredelennokhm a ratio. So, AA. Goffmann and sotr. established that at the expressed damages of skin at tuberculosis or plentiful syphilides at syphilis there is no intensive damage of internals. It is known also that defeat of a nervous system at syphilis is not followed by syphilides. Expression «a tuberculosis cutis protects an organism from a pulmonary tuberculosis and other bodies» did not lose completely the value to a crust, time. E. M. Tareev (1965) points to «antagonism» of damages of skin and internal opraj is new in the third period of a system lupus erythematosus.

Skin (see) takes part in processes of immunity, thanking the Crimea the organism quickly reacts to influence of microbes, vaccines and allergens. On A. V. Lizgunova's (1959) observations, an intradermal way of immunization of mice staphylococcal toxin, streptococcal and staphylococcal vaccines or vaccines you. Typhi murium yields the best result, than hypodermic. A. D. A to and A. V. Guo-lyaev (1938) observed that development of a skin phenomenon of Artyus (see Ar-tyusa a phenomenon) at rabbits slows down emergence it in internals. These data specify that reactivity of skin plays a part in developing of various pathology of internals and needs further researches.

Protective properties of skin increase at impact on it, e.g., of heat, suberythema doses of UF-ob-lucheniya, massage. In these cases, apparently, skin cosecretes biologically active agents changing reactivity and resistance of an organism to pathogenic influences. In skin biologically active agents which are exerting impact on an organism in general, taking part in inflammatory, regenerator or dystrophic processes of skin are synthesized. So, it is established that in sebaceous glands many are synthesized unsaturated fat to - you; in skin there is a synthesis of prostaglandins (see), to-rye come to blood at patol. states; at burns in skin of the person the proteases dissolving fibrin (see) are found.

Bibliography: And d about A. D. and about l I e in A. V. K to a question of a comparative anafilaktiza-tion of bodies, Bulletin ekspery. biol. and medical, t. 6, century 5, page 547, 1938; Gamaley N. F. Fundamentals of immunology, page 154, M. — JI 1928; Tareev. M. Collagenoses, M., 1965; Hoffmann E. Uber eine nach innen gerichtete Schutzfunktion der Haut (Esophylaxie) nebst Bemerkungen neber die Entstehung der Paralyse, Dtsch. med. Wschr., S. 1233, 1919; about N of e, t)ber die nach innen gerichtete Schutz-und Heil-kraft der Haut (Esophylaxie), Derm. Z., Bd 59, S. 155, 1930; R a m w e 1 1 P. Prostaglandins, v. 1, p. 189, N. Y., 1973.

A. D. Ado.