ETHYLENE DIAMINE TETRAACETIC ACID DISODIUM SALT (Dinatrii aethylendiamintet-raacetas; synonym: Trilonum of B, Calsol,
Dinatriumedetat, Natrii edetas, Sodium edetate, Trilon B, etc.) — complexing connection. Disodium salt ethylene diamine tetraacetic to - you; C10H14N2Na2O8-2H2O:
White crystal powder, water soluble, almost insoluble in alcohol and ether.
Drug concerns to group of complexons (see). From a digestive tract it is soaked up only apprx. 5 — 20% of the accepted dose, and other quantity (80 — 95%) is removed through went. - kish. a path during the 24th hour. The half-cycle of circulation of drug in blood at intravenous administration makes apprx. 60 min. It is distributed in an organism evenly, generally in extracellular liquid. At normal secretory function of kidneys in 4 hours after intravenous administration it is removed with urine apprx. 80% of drug, and to 24 hours — St. 95%.
Drug forms stable complexes with bivalent metals, including calcium. In this regard it is applied preferential at a hypercalcemia, at
the diseases which are followed by excess adjournment of salts of calcium in an organism, napr at patol. ossifications of a skeleton, joints, muscles, kidneys, walls of veins, at a scleroderma (see) and porphyrias (see). Besides, it is used for binding of calcium in the course of treatment of nek-ry forms of the ectopic arrhythmias including which arose at overdose of cardiac glycosides (see) and also as anticoagulant at conservation of blood. In pharmacy, analytical chemistry and biochemistry this drug is used for binding of heavy metals in environments.
Enter intravenously kapelno on 2 — 4 g into 500 ml 5% of solution of glucose during 3 — 4 hours or it is fractional every 6th hour. Course of treatment of 3 — 6 days. A repeated course is conducted in 1 week. Treatment is performed under control of content of calcium in blood, by conditions of water and electrolytic balance, function of kidneys, cardiovascular system and a gemogramma.
Side effects (a frequent urination, an albuminuria, and - ami-noatsiduriya, a glucosuria) are connected with development of destructive changes in proximal departments of renal tubules. These changes are reversible, and the specified symptoms usually pass after drug withdrawal. At intravenous administration emergence of the burning extending on all body, thrombophlebitis in the field of an injection is possible. In some cases in 4 — 8 hours after administration of drug the fever and fever appear, to-rye are followed by the general weakness, thirst, strong muscular and headaches. Besides, injury of a mucous membrane of a small bowel is noted, a cut proceeds with anorexia, nausea and vomiting. At bystry introduction to a vein tetanic spasms are possible, and hemorrhagic diathesis sometimes develops. In some cases drug can cause histamine-like reactions (cold, dacryagogue, dermatitis), and also anemia, hypotension and bradycardia. The majority of complications passes after its cancellation and introduction of a gluconate of calcium, Dimedrol, rat anti-acrodynia factor. At the heavy renal failures caused by drug resort to a hemodialysis (see).
Drug is contraindicated at hemophilia, the raised bleeding, a hypocalcemia, diseases of kidneys and a liver.
Form of release: powder. Storage: in the dry, protected from light place.
Bibliography: Ludevig R. and Los To * Acute poisonings, the lane with it., M., 1983; Metal-binding in medicine, ed. by M. J. Seven, p. 82, Philadelphia, 1960;
ETHYL MORPHINE macological basis of therapeutics, ed.
by A. G. Gilman and. o., N «, Y., 1980.
F. P. Trinus.