ETHANOLAMINES

From Big Medical Encyclopedia

ETANOLAMYNY (r-hydroxyethyls-ny) — organic compounds from group of amino alcohols. Ethanolamine is one of polar components of lipids biol. membranes (see Membranes biological). In an organism of animals, at plants and microorganisms there is a monoethanol amine, or a stake amine — a component of phospholipids of kephalins (see Phosphatides) and the initial biosynthetic predecessor of sincaline (see) which is three - methylethanolamine. Nek-ry ethanolamines serve as intermediate compounds at synthesis of a number of pharmaceuticals: e.g., r (N, N' - a diethyl of amine) ethanol amine is used in synthesis of novocaine.

The general formula of RR'NCH2CH2OH ethanolamines, where R and R' — hydrogen atoms or hydrocarbon radicals. AA. soluble in chloroethane, low solubility in hydrocarbons and ether represent the viscous hygroscopic liquids which are mixing up with water and alcohols. AA. form alcoholates, with mi-


neralny and strong organic to-tami (see Acids and the bases) — crystal salts (see), with fatty acids (see) — the neutral derivatives applied by production of emulsifiers, washing and cosmetics, the softening reagents for production of anticorrosive connections, absorbers of acid gases (carbon dioxide gas, sulfur dioxide, hydrogen sulfide, hydrogen cyanide) from industrial gas mixtures. Ethanolamines possess irritant action on skin, maximum allowable concentration of vapors E. in air of a working zone makes 1 mg/m3.

Depending on number of the etanol-ny remains at a nitrogen atom exist monoethanol amine (colamine; H2NCH2CH2OH), diethanol amide [HN (CH2CH2OH) 2] and trietanolamine [N (CH2CH2OH)3]. Temperatures of melting of these E. are equal (in the above-stated order) 10,5 °; 27,8 °; 21,2 °; temperatures of boiling 171,1 °; 271 °; 360 °; relative density at 20 ° 1,0179; 1,0919; 1,1258. In the industry E. usually receive interaction of ammonia (see) with ethylene oxide (see. Organic compounds) or from etilenkhlorgidri-number.


Biosynthesis of colamine at animals and the person is carried out by enzymatic decarboxylation (see) amino acids of serine (see). The catabolism of colamine occurs according to the scheme colamine — ► hydroxy-acetaldehyde —> glycolic to - that is> glioksilevy to - that is * glycine (see) with the participation of enzymes of an etanolamino-ksidaza (KF 1.4.3.8), glikolyal-degid-dehydrogenase (KF 1.2.1.21), etc.

Colamine is antioxidant (see Antioxidants), it slows down an autookisleniye of fats (see), and its complex with copper possesses pro-oxide antny action.

Colamine stimulates growth of nek-ry farm animals in a dose of 5 — 10 mg/kg. Besides, colamine is used for treatment of a number of functional disorders of digestive tract at ruminants.

By quantitative and qualitative methods of definition E. methods of hromatografichesky identification of these substances by means of a gas liquid chromatography (see), a chromatography of high pressure or definition in the aminoacid analyzer are. In blood serum E. determine by method of a chromatography. Healthy people have an abundance of ethanolamine together with serinfosfa-tidy in blood serum makes 6 — 7% (sometimes to 12%) from the general content of phospholipids.

Bibliogrkamalyan G. V. Colamine — a new growth-promoting factor, M., 1966; Lenindzher A. Biochemistry, the lane with English, page 231, 608, M., 1976;

Shtraub F. B. Biokhimiya, the lane from veins-ger., Budapest, 1965. V. A. Pekkel.

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