ERGOTAMYN (Ergotaminum) — the means stimulating a tone and sokratitelny activity of a myometrium; alkaloid of an ergot (Secale cornutum). In medical practice it is applied in the form of ergotamine of hydrotartrate (Ergotamini hydrotartras; synonym: Er-gotartrat, Gynergen, etc.; joint venture. А).] H - (2-hydroxy-1-methylethyl) - 0-lizer-gamida tartrate; (СззНз^505) 2. S4nv06:
Crystal powder from white till inodorous grayish color, we will dissolve in water and alcohol a little. Pier. weight (weight) 1313,44.
Raises a tone and causes strong and long reductions of muscles of a uterus. Action E. it is shown in 15 — 20 min. after introduction and lasts 1 — 2 hour. In rather high doses has adrenoceptor blocking properties. At parenteral administration E. raises the ABP, causing narrowing of arterioles. On c. the N of page renders the action in the beginning exciting, and then oppressing.
The voobrashcheniye influences a brain kro-, lowering amplitude of a pulsation of vessels of a brain. In small doses E. expands a pupil, in big — causes its narrowing.
At hydrolysis E. lysergic acid (see), 1 alanine, pyroracemic to - that, etc. is formed. After introduction inside E. it is quickly metabolized and only in small amounts it is removed in not changed view with urine.
Apply E. at the uterine bleedings caused by hypotonia of a uterus for acceleration of involution of a uterus after the delivery and abortion, at menorrhagias, and also in nevrol. to practice for treatment of migraine, vegeto-vascular dystonia.
Appoint inside on 1 tablet (0,001 g) or 10 — 15 drops of 0,1% of solution 2 — 3 times a day. Subcutaneously or intramusculary enter on 0,5 — 1 ml 0,05% of solution within 7 days (no more). Prolonged use is dangerous in connection with a possibility of development of intoxication (ergotism). If necessary the course of treatment can be repeated in 3 — 5 days. The highest single doses for adults in 0,002 g, subcutaneously — 0,0005 g the Highest daily doses inside — 0,004 g, subcutaneously — 0,002 g.
Side effect E. it is shown by dispeptic disorders, blanching of the face, a cold snap of extremities, paresthesias, sometimes — allergic reactions and increase in the ABP.
It is contraindicated at pregnancy, in the first and second periods of childbirth, at diseases of peripheral vessels, stenocardia, sepsis. With care apply at diseases of a liver, kidneys, atherosclerosis.
Form of release: tablets (dragee) on 0,001 g, bottles on 10 ml of 0,1% of solution (1 ml contains 1 mg of drug), ampoules on 1 ml of 0,05% of solution (1 ml contains 0,5 mg of drug). Storage: in the place protected from light at a temperature not over 10 °. Ya. I. Hadzhay.