ENTEROGASTRYN — the hormone produced by a mucous membrane of preferential upper parts of a small bowel, stimulating activity of gastric glands.
Studying of mechanisms of gastric secretion allowed to establish that secretory cells of a stomach are excited not only gastrin (see) and to it the similar substances which are contained in a mucous membrane of a stomach but also a number of the substances which are in a mucous membrane of a duodenum, upper and average departments of a jejunum. In particular, the promoting effect on a pepsinia of secretin and crude pancreozymin was noted.
I. P. Razenkov in 1948 came to a conclusion that the special chemical substances called by it intestinal secretins take part in regulation of the second phase of secretion of a gastric juice. A. M. Vorobyov (1948) in experiences on dogs with the Pavlovsk ventricle (see the Ventricle isolated) showed that hypodermic or intravenous administrations of muriatic extracts from a mucous membrane of upper and average departments of a small bowel excite secretion of an acid gastric juice. Because extract from a mucous membrane of an ileal gut had no similar property, the conclusion was drawn on specificity of the substances which are formed in a small bowel. I. T. Kurtsin suggested to combine all substances having the hormonal nature and called by intestinal secretins the term «en-terogastrina».
As a rule, the main source of gastrin is localized in an antral part of a stomach, however Watson (L. Page of Watson) with sotr. (1964) and Yalou (R. S. Yalow, 1975) found gastrin - and a gastrinopodobny immunoreactivity in upper parts of a small bowel. In addition to the G-cells producing gastrin in a small bowel also gastrins — the linear polypeptides containing respectively 17 and 34 amino-acid rests are revealed (— 17 and — 34). Fiziol. action E. it is very similar to effect of gastrin. Assume that allocated as E. protein fraction in addition to gastrin may contain also other intestinal hormones like bombesin, to-rye, in turn, stimulate release of gastrin from G-cells of a mucous membrane of antral department of a stomach. There are data that to a bomb-zinopodobnye polypeptides can be in a mucous membrane went. - kish. a path of mammals, playing, apparently, a role of a local rileasing-factor (see. Hypothalamic neurohormones) for intestinal hormones.
Bibliography: Klimov P. K. Peptides and alimentary system, L., 1983;
Kurtsin I. T. Hormones of the alimentary system, M. — L., 1962; Razenkov I. P. New data on physiology and pathology of digestion, M., 1948;
Ugolev A. M. Enterinovaya (intestinal hormonal) system, L., 1978; Gastrointestinal hormones, ed. by J. Page of Thompson, p. 25, Austin — L., 1975; U y n a s B. Digestion, Ann. Rev. Physiol., v. 18, p. 145, 1956; Watson L. G. a. o. Gastrin concentrations in upper gastrointestinal mucosa in dogs, Surgery, v. 76, p. 419, 1974. V. G. Zilov.