From Big Medical Encyclopedia

ENTEROANTHELONE — the hypothetical hormonal factor developed by a mucous membrane of a small bowel and which is slowing down secretory and motor functions of a stomach.

In I. P. Pavlov's laboratory it was established that consumption by animals of fat or the food containing fat causes gastric secretion after long stage of latency. The analysis of this phenomenon allowed I. P. Pavlov to assume that braking of gastric secretion happens in the humoral way to participation of a duodenum. In 1926 Mr. Farrell and Ivy (J. I. Farrell, A. S. Ivy) in experience with a ventricle, isolated and transplantirovanny under skin, showed that the fat arriving in went. - kish. the path, slows down secretion salt to - you in a ventricle and oppresses him a physical activity. The conclusion was drawn on participation in this process of hormone by Valyavski (J. Walawski, 1928) on the basis of experiments with biodialyzate — the solution containing waste products of tissues of large intestine. Kosaka and Lim (T. Kosaka, R. K. - S. Lim, 1930) found out that extracts from upper parts of intestines slow down activity of a stomach at parenteral administration, and in this case the brake effect did not differ from brake effect during the finding of fat in a duodenum. On this basis Kosaka and Lim drew a conclusion on existence in a small bowel of the special hormone which is slowing down functions of a stomach and called it enteroanthelone.

Further researches confirmed that E. the hl is formed. obr. in a mucous membrane of a duodenum and upper parts of a jejunum. It was revealed also that E. in addition to braking of activity of gastric glands, at the same time oppresses motor evakua - even function of a stomach. It forced to assume existence in E. two effective agents, one of to-rykh provides braking of secretion, another — motility. Property E. to slow down gastric secretion it was used in a wedge, practice at treatment of hyperacid and hyper secretory gastritises (see) and especially peptic ulcer (see) which is followed by the increased secretory activity of gastric glands. As drug the extract cleared on a way by Ivy from a mucous membrane of an upper part of a small bowel of pigs was applied. The single dose of drug at intramuscular introduction made 100 mg a day.

However in a crust, time existence E. began to raise doubts. This results from the fact that still nobody managed to receive E. in pure form. Besides, many identified hormones went. - kish. a path possess the expressed brake action on secretion salt to - you a stomach (e.g., vazointestinalny polypeptide and gastroingibiruyushchy polypeptide). In this regard assume that E. it is identical to the gastroingibiruyushchy polypeptide (GIP) which is emitted from a small intestine under the influence of fat. GIP (pier. weight apprx. 5100), consisting of 43 amino-acid remains, is allocated from a mucous membrane of an upper part of a small bowel of pigs and cleared. Results of intravenous administration of GIP animal showed that it can cause several effects — to slow down secretion salt to - you a stomach (ente-rogastronovy effect), to stimulate release of insulin (inkretino-vy effect), to stimulate intestinal secretion (enterinovy effect) and to brake motility of a stomach. The pork GIP entered to the person intravenously caused the effects characteristic as for E., and for insulin (see).

Bibliography: Klimov P. Kya Peptides and alimentary system, L., 1983;

Kurtsin I. T. Hormones of the alimentary system, M. — L., 1962; Ugolev A. M. Enterinovaya (intestinal hormonal) system, L., 1978; Physiology of digestion, under the editorship of A. V. Solovyov, etc., L., 1974; Farrell J. I. and * A. S's Ivy. Studies on the motility of the transplanted gastric pouch, Amer, J. Physiol., v. 76, p. 227, 1926; Kosaka T. Lim R. K. S. Demonstration of the humoral agents in fat inhibition of gastric secretion, Proc. Soc. exp. Biol. (N., Y.) f v. 27, p. 890, 1930; Walawski J. Les biodialysats intestinaux, agents inhibiteurs de la of s£cr6tion gastrique, C. R. Soc. Biol, (Paris), t, 19, p. 1169, 1928,

V. G. Zilov.