From Big Medical Encyclopedia

EJLJER-HOELPIN Hans (Euler-Chelpin Hans Karl August Simon, 1873 — 1964) is the Swedish chemist and the biochemist, the member of Royal Swedish academy of Sciences, the foreign member correspondent of Academy of Sciences of the USSR (1927), the member London royal about-va, the Nobel Prize laureate (1929).

Graduated from the Munich academy of Arts (1893), studied chemistry and medicine in high fur boots of Berlin, Strasbourg, Goettingen. Worked in Nernst's laboratories (W. Nernst, 1895). S. Arrhenius (1897), Ya. Vant Hoff (1899), in Pasterovskom in-those in Paris. Since 1900 the associate professor, and since 1906

professor of the general and inorganic chemistry Stockholm un-that. In 1929 headed biochemical institute in the same place, in Krom the last years of life directed laboratory.

X. Euler-Hel-ppn made an essential contribution to development of various fields of chemistry and biochemistry. He studied transformations of carotene (see) in vitamin A (see Retinolum); obtained important data on structure of ascorbic acid (see) and related connections by it. It possesses a number of fundamental works in the area enzimologsht. X. Euler-Hel-pgtn investigated the mechanism of effect of dipeptidases, in particular education enzyme - a substrate complex. Its most outstanding works are devoted to studying of structure and function of the major coenzyme opened by A. Harden and W. Young — OVER (see. kotinamid adenindinukleo-tid). As a result of consistently carried out careful cleaning of X. Euler-Helschgna together with Mirbek (To. Myrback) was succeeded to receive the solution by 500 — 800 times surpassing initial substrate in enzymatic activity. It allowed to establish a pier. the weight (weight) OVER to determine content in its molecule of adenine, pentose (ribose) and to be convinced of loss of coenzymatical activity by it during the processing by enzyme nucleosidase. Further X. Euler-Helyiin with sotr. it was found out what OVER is an obligatory participant of processes of fermentation and tissue respiration (see biological oxidation). The Nobel Prize is conferred together with A. Harden for works on biochemistry.

X. Euler-Helpin was a member of a number of foreign academies and scientific about - century

of Works: Chemie der Enzyme, Bd 1 — 2, Miinchen, 1925 — 1928; Enzymchemische Studien iiber Hamolyse, Uppsala, 1929 (sovm. with Brunius E.); Biochemie der Tumoren, Stuttgart, 1942 (sovm. with Skarzynski B.); Chemie und Biochemie derReduktone und Redukto-nate, Stuttgart, 1957 (sovm. with Eistert B.).

Bibliography: F a r b e r E. Nobel prize winners in chemistry, 1901 — 1950, p. 112, N. Y., 1953; The international who’s who, p. 304, L., 1962 — 1963. C.E. Severin.