DROPERIDOLUM (Droperidolum; synonym: Dehydrobenzperidol, Droleptan, Inapsin; joint venture. B) — neuroleptic. 1-[3-(para-Ftorbenzoil) - propyl]-4-(1-benzimidazolinon-2) - 1,2,3,6 tetrahydropyridine:
On a structure and pharmakol, to properties D. it is close to to a haloperidol (see). Being a typical neuroleptic, D. causes bystry approach of the calming effect which is characterized by depth at rather small duration of action. Exerts the selective oppressing impact on conditional defensive reflexes, reduces a spontaneous physical activity, causes antiemetic effect, a katalepsy and deep motive block. Feature of drug — the expressed antishock action. Does not exert considerable impact on cardiovascular system and century of N of page. Drug considerably strengthens effect of narcotic substances and muscle relaxants, shows antagonism in relation to the central effects of Apomorphinum and Phenaminum (prevention of a motor stereotypy).
Widely apply in anesthesiology and resuscitation for neyroleptanalgeziya (see) in combination with fentanyl (see), and also in emergency treatment of a myocardial infarction, stenocardia and fluid lungs. In D.'s psychiatry use as sedative for stopping of a condition of excitement. Drug is used also for premedication in the preoperative period, for potentiation of an introduction anesthesia, and also in the course of operation in combination with nitrous oxide, ether or Ftorotanum. In the postoperative period drug can be used as a calmative, for removal of postoperative pains, and also at tool researches and diagnostic procedures.
For premedication and decrease in pains of D. appoint intramusculary in a dose 2,5 — 5 mg (1 — 2 ml of 0,25% of solution) in combination with fentanyl and atropine; for potentiation of an introduction anesthesia — intravenously (usually kapelno) 5 — 12,5 mg, in some cases to 25 mg together with fentanyl; at emergency treatment of a myocardial infarction and stenocardia — intravenously 2,5 — 5 mg of D. in combination with fentanyl in 20 ml of 5 — 40% of solution of glucose. Apply D. only in the conditions of a hospital. At D.'s treatment it is necessary to control constantly a condition of cardiovascular and respiratory systems. It is necessary to be careful at D.'s use for children, for the patients treated by antihypertensives, corticosteroids, insulin for patients with the expressed atherosclerosis, disturbance of conductivity of a cardiac muscle, the phenomena of a cardiovascular decompensation.
Is contraindicated at convulsive states, including extrapyramidal frustration, poisoning with drugs, hypnotic drugs and other depriving of bonuses (oppressing) substances. Does not exert negative impact on functions of a liver and D.'s kidneys that allows to consider neyroleptanalgeziya) means of the choice at patients with disturbances of functions of a liver and kidneys.
Forms of release: 0,25% solution in ampoules on 10 ml. The combined drug thalamonal containing in 1 ml 2,5 mg of D. and 0,05 mg of fentanyl is produced in ampoules on 2 ml and in bottles on 10 ml.
See also Antipsychotic means .
Bibliography: Darbinyan T. M. Neuroleptanalgesia, M., 1969, bibliogr.; To au-lyutsky O. D. and Bitsunov N. S. Use of Droperidolum and fentanyl in the emergency anesthesiology, Surgery, No. 4, page 54, 1973; Kondratovich M. A., Meleshchenko And, And. igorpinchen-to about E. I. Analysis of the mechanism of vasodilating action of Droperidolum, Cardiology, No. 2, page 53, 1974, bibliogr.
K. S. Rayevsky.