From Big Medical Encyclopedia

DIHYDROERGOTOXIN (Dihydroergotoxinum) — adrenolytic means. Mix of equal parts of the dihydrogenated alkaloids ergot (see) — a digidroergokristina, a digidroergokornina and a digidroergokriptina.

On adrenoceptor blocking activity and the oppressing influence on c. N of page the dihydrogenated derivatives considerably surpass natural alkaloids (ergokristin, ergokornin and ergokriptin); they by about 20 times are less toxic, have practically no direct promoting effect on smooth muscles of blood vessels, a uterus and other bodies. Blocks hl. obr. alpha adrenoceptors.

On character and the mechanism of adrenolytic action and influence on c. the N of page D. significantly does not differ from dihydroergotamine (see). The hypotensive effect is caused more by its central action. In the conditions of blockade of carrying out impulses on sympathetic nerves (use of ganglioblokator, sympatholytics) D. can cause vasoconstrictive effect. Like dihydroergotamine D. excites the emetic center, raises a tone of a vagus nerve and slows down a cordial rhythm.

It is made abroad. Is issued in the form of salts — an etansulfonat (e.g., Redergamum) or Methansulfonas natricum (e.g., DN-Ergotoxin).

See also Adrenolytic means .

Bibliography: Komissarov I. V. Medicinal regulation of adrenergic processes, Kiev, 1976, bibliogr.; Nickerson M. a. Hollenberg N. To. Blockade of a-adrenergic receptors, in book: Physiological pharmacology, ed. by W. S. Root a. F. G. Hofmann, v. 4, p. 243, N. Y. — L., 1967, bibliogr.; The pharmacological basis of therapeutics, ed. by L.S. Goodman a. A. Gilman, L., 1975.

M. Ya. Melzob.