DIBENZANTHRACENE

From Big Medical Encyclopedia

DIBENZANTHRACENE [Dibenz (a, h) anthracene; synonym: 1,2,5,6 dibenzanthracene, 1,2,7,8 dibenzanthracene, dibenz (a, h) - anthracene, DBA] — the first (on time of studying) oncogenous politsiklicheeky aromatic hydrocarbon, C 22 H 14 .

Represents the colourless plates reddening in the concentrated chamois to - that, well soluble in the majority of organic solvents and oils, it is weak — in alcohol and ether, almost water-insoluble; pier. weight (weight) 278,35, t ° pl 266 °.

Was synthesized by E. Clar in 1929, and in 1930 in animal experiments of E. Kenneuey established his oncogenous activity. Numerous works proved its Oncogenous properties — ability to cause both malignant, and benign tumors in mice, rats, rabbits, Guinea pigs, hens and other laboratory animals on site of administration of drug and far from it. Though D.'s activity is approximately twice weaker, than activity benzpyrene (see), however at hypodermic repeated introduction of small doses of D. it was not less effective, than benzpyrene and 3-metilkholantren; and stage of latency at D.'s action is more long.

For D.'s definition different types of the stratographic and spectral and fluorescent analysis are used.

Data on effect of drug on the person are absent. However it is revealed that the coal tar, soot and other substances known for the carcinogenicity for the person, may contain a nek-swarm

D. D. number use in pilot studies for induction of tumors at laboratory animals.

See also Oncogenous substances .


Bibliography: Bedzher G. M. Chemical bases of carcinogenic activity, the lane with English, M., 1966, bibliogr.; L. M Sabbath. Sketches of experimental oncology, M., 1947, bibliogr.; Burrows H., Hieger I. Kenna-w a y E. L. Experimental production of tumors of connective tissue, Amer. J. Cancer, v. 16, p. 57, 1932; Clar E. Zur Kenntnis mehrkerniger aromatischer Koh-lenwasserstoffe und ihrer Abkommlinge, Ber. dtsch. chem. Ges., Bd 62, S. 350, 1929.

AA. E. Smetanin, L. M. Shabad.

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