DIBENZACRIDINE

From Big Medical Encyclopedia

DIBENZACRIDINE [Dibenz (a, h)acridine; synonym: 1,2,5,6 dibenzacridine, 1,2,5,6 dinaphthacre and dynes, DBAK] — the heterocyclic compound having oncogenous properties, C 21 H 13 N.

Yellow crystal substance, sparingly soluble in ethanol; pier. the weight (weight) — 273; t ° pl 228 °. On chemical properties it is very close to acridine. Is formed as a result of incomplete combustion of fuel.

Oncogenous properties D. were studied in experiences on mice. On skin, in the field of application of solution D. there are papillomas and cancer, and at its hypodermic introduction — local sarcomas; considerably the number of spontaneous tumors of lungs at mice increases. Oncogenous activity of D. is less expressed, than activity of the homologous hydrocarbon corresponding to it dibenz (a, h) - anthracene (see. Dibenzantratsen ).

Can be found by means of a chromatography, a spektrofotometriya or a spektroflyuorometriya in the environment.

Isomer D. dibenz (a, j) acridine (D1) also has Oncogenous properties that is confirmed in experiences on mice, however they are less expressed, than at. After cutaneous applications of isomer D. there are benign tumors, and at hypodermic introduction of high doses — local sarcomas.

There are no proofs of action of D and D1 on the person. However coal tar and similar to it the substances known for the carcinogenic activity for the person, contain D and D1.

See also Oncogenous substances


Bibliography: Lakassan And., etc. Communication between carcinogenic activity and physical and chemical properties of angular benzacridines, in book: Progress in izuch. cancer, the lane with English, under the editorship of L. M. Shabad, t. 4, page 350, M., 1958; Sh and - and d L. M. Sketches of experimental oncology, M., 1947, bibliogr.; On the evaluation of carcinogenic risk of chemicals to man, Int. agency res. cancer monogr., v. 3, p. 247, 1973.

AA. E. Smetanin, L. M. Shabad

Яндекс.Метрика