DIAZOLINUM (Diazolinum; synonym: Incidal, Incidan, Insidal, Mebhydrolin, Mebhydrolini Napadisylas, Omeril; GF X, SP. B) — antihistamine. 3-Метил-9-бензил-1,2,3,4-тетрагидрокарболина naphthalene-1, 5 disulphonate:
Inodorous white fine-crystalline powder, t ° pl 278 — 280 °, we will badly dissolve in water and organic solvents.
— active antihistaminic drug. H1-gistaminochuvstvitelnye blocks receptors. Eliminates or reduces the majority of the effects caused by a histamine (a contracture of smooth muscle bodies, a chemosis, decrease in the ABP, a bronchospasm). At single administration of drug its action continues to the 72nd hour. In experiences with primed animals anti-anaphylactic
properties D. D. are noted has no analgesic properties, does not strengthen soothing effect of morphine and does not influence duration of the dream caused by alcohol, Chlorali hydras, barbamyl or hexenal. Besides, drug practically does not influence development of the spasms connected with administration of strychnine, arecoline, camphor, Corazolum or nicotine. Transfer of excitement in an upper cervical ganglion at D.'s use does not change. Eliminates the bradycardia arising at irritation of a vagus nerve or introduction of acetylcholine; at the same time hypotensive action of acetylcholine remains. Renders a nek-swarm the irritant action which is replaced by incomplete anesthesia.
Drug considerably does not influence action of the heart, the ABP and breath. Changes from blood and in a functional condition of a liver under the influence of D. are noted.
At a pathoanatomical research of animals who received D. inside the catarral phenomena in a small intestine — a plethora and swelling of a mucous membrane were observed. From other internals of a deviation were not found.
Is well soaked up in went. - kish. path. Toxicity of drug small, therapeutic width considerable.
Apply D. at treatment of allergic dermatitis, neurodermatoses, eczemas, small tortoiseshells, hay fever, a serum disease, a Quincke's disease, rheumatism with the expressed allergic component and other allergic states.
Favorable effect of drug at a capillary toxicosis is noted. Quite often D. yields a positive take when Dimedrol and other antihistaminic means are inefficient. Drug is especially effective at an itch. D.'s advantage in comparison with Dimedrol and isopromethazine (Pipolphenum) is lack of the oppressing influence on c. N of page: it does not cause drowsiness and sedation. It causes D.'s appointment in case of need to persons whose professional activity requires special attention and bystry reactions (to drivers of transport, etc.).
Drug is appointed inside in tablets (dragee), capsules the adult on 0,05 — 0,2 g, children on 0,02 — 0,05 g (1 — 3 time a day). On reaching necessary effect it is possible to be limited to a single dose of D. during 2 — 3 days the Highest doses for adults inside: one-time 0,3 g, daily 0,6 g.
In order to avoid irritating D.'s influence on a mucous membrane of a stomach and intestines it is recommended to accept it after food, it is better capsular or drazhirovanny tablets. Side effects are connected with the irritating properties of drug; are observed seldom. Is contraindicated at inflammatory processes in digestive tract (a peptic ulcer, gastritis, etc.).
Forms of release: powder, tablets (dragee) on 0,05 and 0,1 g. Keep in the container protecting from effect of light; tablets — in the place protected from light.
See also Antihistaminic substances .
D. A. Harkevich