DEYL of Henry

From Big Medical Encyclopedia

DEYL of Henry (Dale Henry Hallett, 1875 — 1968) — the English physiologist and the pharmacologist. Got a medical education in the Cambridge Triniti college (1909), and then worked in laboratory E. Starling.

Henry's DEYL

Since 1914 in National in-those medical researches directed laboratory of physiology (till 1920), department of biochemistry and pharmacology (till 1928), from 1928 to 1942 was the director of it in-that.

In 1939 — 1959 professor of physiology London un-that; at the same time in 1942 — 1946 headed Davy's laboratory — Faraday in Royal in-those.

Scientific research of G. Dale is devoted to mechanisms of momentum transfer from nerve terminations, and also to problems of an allergy. It revealed dependence between a structure and effect of sympathomimetic amines, and also the ethers of sincaline possessing parasympathomimetic action; together with G. Barger and F. Howard allocated Ergotoxinum (1906) and for the first time described adrenolytic properties of alkaloids of uterine horns. G. Dale allocated acetylcholine from a spleen of animals (1929) and established that it is a mediator in transfer of nervous impulses from the terminations of a vagus nerve in a stomach, from sympathetic nerves in sweat glands, from motor nerves in skeletal muscles, and also in vegetative gangliya and a medulla of adrenal glands. G. Deyl entered division of centrifugal nerves on cholinergic and adrenergic depending on the chemical nature of the mediator transferring impulses; established that all terminations of this neuron allocate the same mediator. For works about a role of acetylcholine G. Dale made a big contribution to development of allergology. He for the first time together with P. Laidlaw described and in detail studied fiziol, action of a histamine (1911) on the basis of what created the histamine theory of an acute anaphylaxis. Developing W. Schultz's researches, G. Dale developed the highly sensitive technique of definition of anaphylactic reaction of the isolated smooth muscle bodies (in experiments on the isolated uterus of virgin sensibilized Guinea pigs) which received the name of reaction of W. Schultz in allergology — Dale (see. Shulttsa-Deyl reaction ). By means of this technique it showed that at anaphylactic reactions the major role is played by the antibodies fixed by fabrics. Process of connection of antibodies with offending allergen is followed by release of a histamine which causes sharp and long reduction of unstriated muscles. Using this technique, it is also possible to receive anaphylactic reaction of a uterus and after a passive sensitization. G. Deyl was member Korolevskogo about-va since 1914, in 1925 — 1935 his secretary general, and in 1940 — 1945 the president of it about-va.

Works: The physiological action of B-iminazolylethylamine, J. Physiol. (Lond.), v. 41, p. 318, 1911 (sovm, with Laidlaw P. P.); The action of certain esters and ethers of choline and their relation to muscarine, J. Pharmacol., y. 6, p. 147, 1914; The vaso-dilator action of histamine and of some other substances, J. Physiol. (Lond.), v. 52, p. 110, 1918 (sovm, with Richards A. N.); t)ber humorale Efbertragbarkeit der Herznervenwirkung, Pfliigers Arch. ges. Physiol., Bd 189, S. 239, 1921, Bd 193, S. 201, 1922, Bd 203, S. 408, 1923, Bd 204, S. 361, 1924 (sovm. with Loewi O.); The mechanism of anaphylaxis, Acta allerg. (Kbh.), v. 5, p. 191, 1952.

Bibliography: Ado A. D. General allergology, page 3 10, M., 1970; The 80. birthday of sir Henry Dale, Brit. med. J., v. 1, p. 1355, 1955; Excerpts from classics in allergy, ed. by M. Samter, p. 44, Columbus, 1969.

Yu. L. Guly.