DEXAMETHASONAL TEST — the functional trial based on suppression by dexamethasone of secretion of AKTG an adenohypophysis and decrease in secretion of glucocorticoids and androgens bark of adrenal glands; it is applied to diagnosis of various defeats of bark of adrenal glands.
Dative. it is shown if necessary to differentiate tumors of bark of adrenal glands with its hyperplasia. Carrying out Dative is shown at Itsenko-Cushing of a disease (see), adrenogenital syndrome (see). If at reception dexamethasone (see) decrease in allocation of 17 ketosteroids and 17 oxycorticosteroids with urine is noted, it is possible to think of normal function of bark of adrenal glands or of its functional hyperactivity connected with the hyperplasia which is observed at patients at Itsenko's disease — Cushing, or an inborn hyperplasia of bark of adrenal glands. At patients with tumors of bark of adrenal glands at reception of dexamethasone of decrease in excretion of 17 ketosteroids and 17 oxycorticosteroids does not come.
For conducting test various doses of dexamethasone are recommended. At the small test (small Dative) appoint 2 mg of dexamethasone daily within 2 days. Before administration of drug and in the last day tests define the maintenance of 17 ketosteroids and 17 oxycorticosteroids in daily urine. Lack of decrease in their content in urine after reception of dexamethasone in this dose indicates pathology of bark of adrenal glands (a hyperplasia or a tumor). At big test dexamethasone is entered on 8 mg daily within 2 days. Lack of decrease in maintenance of 17 ketosteroids and 17 oxycorticosteroids in urine speaks about a tumor of bark of adrenal glands.
Bibliography: Menshikov V. V. Methods of clinical biochemistry of hormones and mediators, page 67, M., 1969; Starkova H. T. E.I's imarova. Use of AKTG, metopiron, dexamethasone for differential diagnosis of a disease of Itsenko — Cushing and a kortikoster, Probl, endocrinins, and a gormonoter., t. 16, No. 2, page 16, 1970, bibliogr.; Teter E. Hormonal disturbances at men and women, the lane with polsk., page 394, Warsaw, 1968; L i d d 1 e G. W. Tests of pituitary-adrenal suppressibility of the diagnosis of Cushing’s syndrome, J. clin. Endocr., v. 20, p. 1539, 1960.
V. I. Maximov.