DEVINCANUM (Devincan; synonym: Vincaminum, Pervincamine, Minorin, joint venture. B) — antihypertensive; the alkaloid emitted from a periwinkle (Vinca minor L. and Vinca erecta Rgl. et Schmalh.) this. dogbane family (Apocynaceae). Belongs to derivatives indole (see). Represents methyl ether vinkaminovy to - you:
Has vasodilating effect, hl. obr. on vessels of a brain, reducing their resistance and improving blood supply of a brain, and also hypotensive and weak sedative action. Stimulates reductions of muscles of a uterus.
Apply at an idiopathic hypertensia (I and II stage), especially at a cerebral form (including at crises), system increase in the ABP, neurogenic tachycardia. Appoint inside: the adult on 0,005 — 0,01 g at first 2 — 3, and then 3 — 4 times a day, to children on 0,0025 — 0,005 g 2 — 3 times a day; treatment is carried usually out within several weeks, by the end of a course the dose is gradually reduced. Intramuscular introduction is allowed only in stationary conditions; in the beginning enter on 1 ml 0,5% of solution once a day, then on 1 — 2 ml 2 times a day. At improvement of a state pass to reception of tablets.
Use of drug is contraindicated at pregnancy.
Forms of release: tablets on 0,005 and 0,01 g and ampoules containing 0,005 g of drug. It is made in the Hungarian People's Republic.
See also Antihypertensives .
Bibliography: Pharmacology of alkaloids and cardiac glycosides, under the editorship of M. B. Sultanov, page 23, Tashkent, 1971.
V. V. Parin.