DERATOFIBROMA

From Big Medical Encyclopedia

DERATOFIBROMA (dermatofibroma; Greek derma, dermat [os] skin + fibroma; synonym fibroma of skin dense) — benign connective tissue tumor of skin. For the first time D. described P. Unn in 1894 as simple fibroma, then E. S. Glavche in 1902, and in 1911 — Arning and Lewandowski (E. Arning, F. Lewandowsky) who called it a skin node, ranking as not tumoral educations.

Tumoral nodes on a section of light pink color, sometimes with a yellowish or brownish shade.

Microscopic structure of a deratofibroma: the intertwining collagenic fibers (1) between which spindle-shaped cells are located (2) are expressed.

Microscopically the tumor consists of the intertwining collagenic fibers (fig.) which are usually located in the form of so-called moire structures. Between fibers spindle-shaped cells like fibroblasts, sometimes with existence of the histiocytic elements or foamy cells containing birefringent lipids are found. Vessels of capillary type meet. Elastic fibers in a tumor, as a rule, are absent, the hyalinosis which sometimes is sharply expressed is quite often noted. By it is indistinctly delimited from a derma, epidermis over it it is frequent with signs acanthosis (see) and hyperkeratosis (see).

In a question of an origin and D.'s character of a consensus is not present. Ideas that D. are hypodermic keloids or fibrozirovanny sarcoids have only historical interest. The role of an injury and local inflammatory process in D. Niyemi's emergence is not confirmed by numerous researches (K. M. of Niemi, 1973) considers D. as a kind of fibrogistiotsitarny tumors, including in this group in addition to D. and histiocytoma (see). Gistogeneticheski D. is connected with the perikapillyarny mesenchyma capable to be differentiated towards fibroblastichesky elements.

To Zh. Darya in 1930 ranked as group D. so-called fibrous spots of Lewandowski — the multiple dense, slightly towering over skin small knots collected in symmetric groups. Carry to D. sometimes Touraine polyfibromatosis — the peculiar symptom complex of inborn character which is shown multiple various size and a form the consolidations in skin having a structure of the inflammatory infiltrates which underwent fibrosis. Legitimacy of reference of fibrous birthmarks and a polyfibromatosis to D. is divided not by all.

Are located everywhere, but is more often on the lower extremities, especially on a shin. Usually they are solitarna though can be multiple. Are found in women more often, meet at any age, represent the small painless centers of consolidation or nodes in a derma. Skin in the area D. is usually not changed or slightly pigmented.

Grow extremely slowly.

The differential diagnosis of D. with other tumors of skin is based on results of microscopic examination.

Treatment — operational. Forecast favorable.


Bibliography: Apatenko A. K. Epithelial tumors and malformations of skin, M., 1973; Niyemi K. M. Benign fibrogistiotsitarny tumors of skin, the lane with English, M., 1973; And-n of i n g E. u. Lewandowski F. Noduli cutanei, Arch. Derm. Syph. (Berl.), Bd 110, S. 3, 1911.

A. K. Apatenko.

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